Comparative

OMIA group 1033

Urolithiasis

The chain

From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.

  1. Animal disease

    Reached

    OMIA records it in 30 species entries marked as a defect.

  2. Human disease

    Reached

    2 Mondo diseases.

  3. Human gene

    Reached

    1 human gene.

  4. Target evidence

    Reached

    1 Open Targets association, with a best score of 0.78.

  5. Drugs

    Stopped here

    No ChEMBL drug acts on a human gene of the group's target evidence.

The chain stopped at Drugs: No ChEMBL drug acts on a human gene of the group's target evidence.

Natural-model score

How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.

hypouricemia, renal, 2

62.4 out of 100

Part Computed from Points
Target evidence Open Targets score of 0.78 27.4 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog One to one ortholog 20.0 of 20
Both routes One route found this disease 5.0 of 10
Species 30 naturally occurring species entries marked as a defect 10.0 of 10
hypouricemia, renal 1

35.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog One to one ortholog 20.0 of 20
Both routes One route found this disease 5.0 of 10
Species 30 naturally occurring species entries marked as a defect 10.0 of 10

Species

The chain follows only the species entries that OMIA marks as a defect.

Species Scientific name OMIA entry A defect
American mink Neogale vison OMIA:001033-452646 Yes
Arabian camel Camelus dromedarius OMIA:001033-9838 Yes
Atlantic salmon Salmo salar OMIA:001033-8030 Yes
Bactrian camel Camelus bactrianus OMIA:001033-9837 Yes
bush duiker Sylvicapra grimmia OMIA:001033-119562 Yes
dog Canis lupus familiaris OMIA:001033-9615 Yes
domestic cat Felis catus OMIA:001033-9685 Yes
domestic cattle Bos taurus OMIA:001033-9913 Yes
domestic ferret Mustela putorius furo OMIA:001033-9669 Yes
domestic guinea pig Cavia porcellus OMIA:001033-10141 Yes
domestic yak Bos grunniens OMIA:001033-30521 Yes
Dusky leaf-monkey Trachypithecus obscurus OMIA:001033-54181 Yes
European bison Bison bonasus OMIA:001033-9902 Yes
Francois's langur Trachypithecus francoisi OMIA:001033-54180 Yes
goat Capra hircus OMIA:001033-9925 Yes
guanaco Lama guanicoe OMIA:001033-9840 Yes
horse Equus caballus OMIA:001033-9796 Yes
Javan langur Trachypithecus auratus OMIA:001033-222416 Yes
llama Lama glama OMIA:001033-9844 Yes
long-tailed chinchilla Chinchilla lanigera OMIA:001033-34839 Yes
maned wolf Chrysocyon brachyurus OMIA:001033-68728 Yes
mountain tapir Tapirus pinchaque OMIA:001033-30582 Yes
pig Sus scrofa OMIA:001033-9823 Yes
Red shanked douc langur Pygathrix nemaeus OMIA:001033-54133 Yes
Rhesus monkey Macaca mulatta OMIA:001033-9544 Yes
scimitar-horned oryx Oryx dammah OMIA:001033-59534 Yes
sheep Ovis aries OMIA:001033-9940 Yes
Siberian chipmunk Tamias sibiricus OMIA:001033-64680 Yes
Silvery lutung Trachypithecus cristatus OMIA:001033-122765 Yes
western gray kangaroo Macropus fuliginosus OMIA:001033-9316 Yes

Genes

Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.

Species Animal gene Human gene Ortholog
American mink No gene OMIA records no gene for this species entry.
Arabian camel No gene OMIA records no gene for this species entry.
Atlantic salmon No gene OMIA records no gene for this species entry.
Bactrian camel No gene OMIA records no gene for this species entry.
bush duiker No gene OMIA records no gene for this species entry.
dog SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 NCBI Gene 479093 SLC2A9 Ensembl one to one
domestic cat No gene OMIA records no gene for this species entry.
domestic cattle No gene OMIA records no gene for this species entry.
domestic ferret No gene OMIA records no gene for this species entry.
domestic guinea pig No gene OMIA records no gene for this species entry.
domestic yak No gene OMIA records no gene for this species entry.
Dusky leaf-monkey No gene OMIA records no gene for this species entry.
European bison No gene OMIA records no gene for this species entry.
Francois's langur No gene OMIA records no gene for this species entry.
goat No gene OMIA records no gene for this species entry.
guanaco No gene OMIA records no gene for this species entry.
horse No gene OMIA records no gene for this species entry.
Javan langur No gene OMIA records no gene for this species entry.
llama No gene OMIA records no gene for this species entry.
long-tailed chinchilla No gene OMIA records no gene for this species entry.
maned wolf No gene OMIA records no gene for this species entry.
mountain tapir No gene OMIA records no gene for this species entry.
pig No gene OMIA records no gene for this species entry.
Red shanked douc langur No gene OMIA records no gene for this species entry.
Rhesus monkey No gene OMIA records no gene for this species entry.
scimitar-horned oryx No gene OMIA records no gene for this species entry.
sheep No gene OMIA records no gene for this species entry.
Siberian chipmunk No gene OMIA records no gene for this species entry.
Silvery lutung No gene OMIA records no gene for this species entry.
western gray kangaroo No gene OMIA records no gene for this species entry.

Human diseases

Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.

Mondo disease Name Found by
MONDO:0020728 hypouricemia, renal 1 OMIA's OMIM numbers
MONDO:0012793 hypouricemia, renal, 2 OMIA's OMIM numbers

Target evidence

Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.

Human gene Human disease Score Evidence Kinds of evidence
SLC2A9 hypouricemia, renal, 2 0.78 147 Genetic association 0.92 Genetic literature 0.83 Animal model 0.41 Literature 0.25

Drugs

No ChEMBL drug acts on a human gene of the group's target evidence.