Comparative

OMIA group 1818

Factor XIII deficiency, F13A1-related

The chain

From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.

  1. Animal disease

    Reached

    OMIA records it in 2 species entries marked as a defect.

  2. Human disease

    Reached

    1 Mondo disease.

  3. Human gene

    Reached

    1 human gene.

  4. Target evidence

    Reached

    1 Open Targets association, with a best score of 0.74.

  5. Drugs

    Reached

    1 ChEMBL drug, 1 approved. None has been tested for this disease.

Natural-model score

How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.

factor XIII, A subunit, deficiency of

65.4 out of 100

Part Computed from Points
Target evidence Open Targets score of 0.74 25.9 of 35
Drugs Drugs act on its genes, but no drug has been tested for this disease 2.5 of 25
Ortholog One to one ortholog 20.0 of 20
Both routes Both routes found this disease 10.0 of 10
Species 2 naturally occurring species entries marked as a defect 7.0 of 10

Species

The chain follows only the species entries that OMIA marks as a defect.

Species Scientific name OMIA entry A defect
dog Canis lupus familiaris OMIA:001818-9615 Yes
domestic cattle Bos taurus OMIA:001818-9913 Yes

Genes

Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.

Species Animal gene Human gene Ortholog
dog F13A1 coagulation factor XIII A chain NCBI Gene 478711 F13A1 Ensembl one to one
domestic cattle F13A1 coagulation factor XIII A chain NCBI Gene 617881 F13A1 Ensembl one to one

Human diseases

Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.

Mondo disease Name Found by
MONDO:0013187 factor XIII, A subunit, deficiency of Both routes

Target evidence

Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.

Human gene Human disease Score Evidence Kinds of evidence
F13A1 factor XIII, A subunit, deficiency of 0.74 136 Genetic association 0.93 Genetic literature 0.81 Animal model 0.28

Drugs

Drugs act on F13A1, but none has been tested for this disease.

Drug Acts on How Latest stage Tested for this disease
Catridecacog F13A1 exogenous protein Approved No

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.