Comparative

OMIA group 243

Cryptorchidism

The chain reaches the human disease cryptorchidism, which Mondo defines as: “The failure of one or both testes of a male fetus to descend from the abdomen into the scrotum during the late part of pregnancy. If not surgically corrected in early childhood, males may be at increased risk for testicular cancer later in life.”

The chain

From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.

  1. Animal disease

    Reached

    OMIA records it in 12 species entries marked as a defect.

  2. Human disease

    Reached

    1 Mondo disease.

  3. Human gene

    Stopped here

    No gene of a species entry marked as a defect reaches a human gene through Ensembl's orthologs.

  4. Target evidence

    Not reached

    The chain stopped before this step.

  5. Drugs

    Not reached

    The chain stopped before this step.

The chain stopped at Human gene: No gene of a species entry marked as a defect reaches a human gene through Ensembl's orthologs.

Natural-model score

How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.

cryptorchidism

25.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs A drug has reached unknown for this disease 5.0 of 25
Ortholog No gene of a naturally occurring entry reaches a human gene 0.0 of 20
Both routes Both routes found this disease 10.0 of 10
Species 12 naturally occurring species entries marked as a defect 10.0 of 10

Species

The chain follows only the species entries that OMIA marks as a defect.

Species Scientific name OMIA entry A defect
alpaca Vicugna pacos OMIA:000243-30538 Yes
Arabian camel Camelus dromedarius OMIA:000243-9838 Yes
dog Canis lupus familiaris OMIA:000243-9615 Yes
domestic cat Felis catus OMIA:000243-9685 Yes
domestic cattle Bos taurus OMIA:000243-9913 Yes
domestic yak Bos grunniens OMIA:000243-30521 Yes
goat Capra hircus OMIA:000243-9925 Yes
horse Equus caballus OMIA:000243-9796 Yes
llama Lama glama OMIA:000243-9844 Yes
pig Sus scrofa OMIA:000243-9823 Yes
puma Puma concolor OMIA:000243-9696 Yes
sheep Ovis aries OMIA:000243-9940 Yes

Genes

Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.

Species Animal gene Human gene Ortholog
alpaca No gene OMIA records no gene for this species entry.
Arabian camel No gene OMIA records no gene for this species entry.
dog No gene OMIA records no gene for this species entry.
domestic cat No gene OMIA records no gene for this species entry.
domestic cattle No gene OMIA records no gene for this species entry.
domestic yak No gene OMIA records no gene for this species entry.
goat No gene OMIA records no gene for this species entry.
horse No gene OMIA records no gene for this species entry.
llama No gene OMIA records no gene for this species entry.
pig No gene OMIA records no gene for this species entry.
puma No gene OMIA records no gene for this species entry.
sheep No gene OMIA records no gene for this species entry.

Human diseases

Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.

Mondo disease Name Found by
MONDO:0009047 cryptorchidism The failure of one or both testes of a male fetus to descend from the abdomen into the scrotum during the late part of pregnancy. If not surgically corrected in early childhood, males may be at increased risk for testicular cancer later in life. Both routes

Target evidence

Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.

The chain did not reach target evidence.

Drugs

The chain did not reach the drugs.