OMIA group 33
Alzheimer-like disease, generic
The chain reaches the human disease Alzheimer disease 2, which Mondo defines as: “An Alzheimer's disease that is characterized by an association of the apolipoprotein E E4 allele.” It reaches 4 more human diseases, listed below.
The chain
From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.
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Animal disease
Reached
OMIA records it in 24 species entries marked as a defect.
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Human disease
Reached
5 Mondo diseases.
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Human gene
Stopped here
No gene of a species entry marked as a defect reaches a human gene through Ensembl's orthologs.
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Target evidence
Not reached
The chain stopped before this step.
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Drugs
Not reached
The chain stopped before this step.
The chain stopped at Human gene: No gene of a species entry marked as a defect reaches a human gene through Ensembl's orthologs.
Natural-model score
How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.
15.0 out of 100
| Part | Computed from | Points |
|---|---|---|
| Target evidence | No Open Targets association with this disease | 0.0 of 35 |
| Drugs | No drug has been tested for this disease, and none acts on its genes | 0.0 of 25 |
| Ortholog | No gene of a naturally occurring entry reaches a human gene | 0.0 of 20 |
| Both routes | One route found this disease | 5.0 of 10 |
| Species | 23 naturally occurring species entries marked as a defect. 1 genetically engineered entry is not counted | 10.0 of 10 |
15.0 out of 100
| Part | Computed from | Points |
|---|---|---|
| Target evidence | No Open Targets association with this disease | 0.0 of 35 |
| Drugs | No drug has been tested for this disease, and none acts on its genes | 0.0 of 25 |
| Ortholog | No gene of a naturally occurring entry reaches a human gene | 0.0 of 20 |
| Both routes | One route found this disease | 5.0 of 10 |
| Species | 23 naturally occurring species entries marked as a defect. 1 genetically engineered entry is not counted | 10.0 of 10 |
15.0 out of 100
| Part | Computed from | Points |
|---|---|---|
| Target evidence | No Open Targets association with this disease | 0.0 of 35 |
| Drugs | No drug has been tested for this disease, and none acts on its genes | 0.0 of 25 |
| Ortholog | No gene of a naturally occurring entry reaches a human gene | 0.0 of 20 |
| Both routes | One route found this disease | 5.0 of 10 |
| Species | 23 naturally occurring species entries marked as a defect. 1 genetically engineered entry is not counted | 10.0 of 10 |
15.0 out of 100
| Part | Computed from | Points |
|---|---|---|
| Target evidence | No Open Targets association with this disease | 0.0 of 35 |
| Drugs | No drug has been tested for this disease, and none acts on its genes | 0.0 of 25 |
| Ortholog | No gene of a naturally occurring entry reaches a human gene | 0.0 of 20 |
| Both routes | One route found this disease | 5.0 of 10 |
| Species | 23 naturally occurring species entries marked as a defect. 1 genetically engineered entry is not counted | 10.0 of 10 |
15.0 out of 100
| Part | Computed from | Points |
|---|---|---|
| Target evidence | No Open Targets association with this disease | 0.0 of 35 |
| Drugs | No drug has been tested for this disease, and none acts on its genes | 0.0 of 25 |
| Ortholog | No gene of a naturally occurring entry reaches a human gene | 0.0 of 20 |
| Both routes | One route found this disease | 5.0 of 10 |
| Species | 23 naturally occurring species entries marked as a defect. 1 genetically engineered entry is not counted | 10.0 of 10 |
Species
The chain follows only the species entries that OMIA marks as a defect.
| Species | Scientific name | OMIA entry | A defect |
|---|---|---|---|
| Atlantic spotted dolphin | Stenella frontalis | OMIA:000033-103590 | Yes |
| black-striped capuchin | Sapajus libidinosus | OMIA:000033-1126382 | Yes |
| Blainville's beaked whale | Mesoplodon densirostris | OMIA:000033-48708 | Yes |
| Chinese tree shrew | Tupaia belangeri chinensis | OMIA:000033-246437 | Yes |
| common bottlenose dolphin | Tursiops truncatus | OMIA:000033-9739 | Yes |
| crab-eating macaque | Macaca fascicularis | OMIA:000033-9541 | Yes |
| Cuvier's beaked whale | Ziphius cavirostris | OMIA:000033-9760 | Yes |
| degu | Octodon degus | OMIA:000033-10160 | Yes |
| dog | Canis lupus familiaris | OMIA:000033-9615 | Yes |
| domestic cat | Felis catus | OMIA:000033-9685 | Yes |
| domestic guinea pig | Cavia porcellus | OMIA:000033-10141 | Yes |
| green monkey | Chlorocebus sabaeus | OMIA:000033-60711 | Yes |
| hamadryas baboon | Papio hamadryas | OMIA:000033-9557 | Yes |
| Indo-pacific bottlenose dolphin | Tursiops aduncus | OMIA:000033-79784 | Yes |
| long-finned pilot whale | Globicephala melas | OMIA:000033-9731 | Yes |
| northern tree shrew | Tupaia belangeri | OMIA:000033-37347 | Yes |
| pig Genetically engineered, not naturally occurring. Not counted in the score. | Sus scrofa | OMIA:000033-9823 | Yes |
| Rhesus monkey | Macaca mulatta | OMIA:000033-9544 | Yes |
| saddleback dolphin | Delphinus delphis | OMIA:000033-9728 | Yes |
| sheep | Ovis aries | OMIA:000033-9940 | Yes |
| short-finned pilot whale | Globicephala macrorhynchus | OMIA:000033-38241 | Yes |
| striped dolphin | Stenella coeruleoalba | OMIA:000033-9737 | Yes |
| white-beaked dolphin | Lagenorhynchus albirostris | OMIA:000033-27610 | Yes |
| white-tufted-ear marmoset | Callithrix jacchus | OMIA:000033-9483 | Yes |
Genes
Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.
| Species | Animal gene | Human gene | Ortholog |
|---|---|---|---|
| Atlantic spotted dolphin | No gene | OMIA records no gene for this species entry. | |
| black-striped capuchin | No gene | OMIA records no gene for this species entry. | |
| Blainville's beaked whale | No gene | OMIA records no gene for this species entry. | |
| Chinese tree shrew | No gene | OMIA records no gene for this species entry. | |
| common bottlenose dolphin | No gene | OMIA records no gene for this species entry. | |
| crab-eating macaque | No gene | OMIA records no gene for this species entry. | |
| Cuvier's beaked whale | No gene | OMIA records no gene for this species entry. | |
| degu | No gene | OMIA records no gene for this species entry. | |
| dog | No gene | OMIA records no gene for this species entry. | |
| domestic cat | No gene | OMIA records no gene for this species entry. | |
| domestic guinea pig | No gene | OMIA records no gene for this species entry. | |
| green monkey | No gene | OMIA records no gene for this species entry. | |
| hamadryas baboon | No gene | OMIA records no gene for this species entry. | |
| Indo-pacific bottlenose dolphin | No gene | OMIA records no gene for this species entry. | |
| long-finned pilot whale | No gene | OMIA records no gene for this species entry. | |
| northern tree shrew | No gene | OMIA records no gene for this species entry. | |
| pig | No gene | OMIA records no gene for this species entry. | |
| Rhesus monkey | No gene | OMIA records no gene for this species entry. | |
| saddleback dolphin | No gene | OMIA records no gene for this species entry. | |
| sheep | No gene | OMIA records no gene for this species entry. | |
| short-finned pilot whale | No gene | OMIA records no gene for this species entry. | |
| striped dolphin | No gene | OMIA records no gene for this species entry. | |
| white-beaked dolphin | No gene | OMIA records no gene for this species entry. | |
| white-tufted-ear marmoset | No gene | OMIA records no gene for this species entry. | |
Human diseases
Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.
- OMIA's own Mondo link: OMIA links the group to no Mondo disease.
- OMIA's OMIM numbers: found a disease.
| Mondo disease | Name | Found by |
|---|---|---|
| MONDO:0007089 | Alzheimer disease 2 An Alzheimer's disease that is characterized by an association of the apolipoprotein E E4 allele. | OMIA's OMIM numbers |
| MONDO:0011913 | Alzheimer disease 3 Alzheimer's disease with an early onset (starts before the age of 65). It is caused by mutations in the PSEN1 gene. | OMIA's OMIM numbers |
| MONDO:0011743 | Alzheimer disease 4 Alzheimer's disease with an early onset (starts before the age of 65). It is caused by mutations in the PSEN2 gene. | OMIA's OMIM numbers |
| MONDO:0100295 | Alzheimer disease, susceptibility to, mitochondrial | OMIA's OMIM numbers |
| MONDO:0007088 | Alzheimer disease type 1 | OMIA's OMIM numbers |
Target evidence
Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.
The chain did not reach target evidence.
Drugs
The chain did not reach the drugs.