Comparative

OMIA group 564

Difference of sexual development, generic

The chain reaches the human disease disorder of sexual differentiation, which Mondo defines as: “A congenital disorder characterized by abnormalities in the development of the sexual characteristics.”

The chain

From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.

  1. Animal disease

    Reached

    OMIA records it in 16 species entries marked as a defect.

  2. Human disease

    Reached

    1 Mondo disease.

  3. Human gene

    Stopped here

    No gene of a species entry marked as a defect reaches a human gene through Ensembl's orthologs.

  4. Target evidence

    Not reached

    The chain stopped before this step.

  5. Drugs

    Not reached

    The chain stopped before this step.

The chain stopped at Human gene: No gene of a species entry marked as a defect reaches a human gene through Ensembl's orthologs.

Natural-model score

How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.

disorder of sexual differentiation

15.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog No gene of a naturally occurring entry reaches a human gene 0.0 of 20
Both routes One route found this disease 5.0 of 10
Species 16 naturally occurring species entries marked as a defect 10.0 of 10

Species

The chain follows only the species entries that OMIA marks as a defect.

Species Scientific name OMIA entry A defect
argali Ovis ammon OMIA:000564-30527 Yes
Australian magpie Gymnorhina tibicen OMIA:000564-9132 Unknown, not counted
bighorn sheep Ovis canadensis OMIA:000564-37174 Yes
chicken Gallus gallus OMIA:000564-9031 Yes
crested pigeon Ocyphaps lophotes OMIA:000564-187128 Unknown, not counted
dog Canis lupus familiaris OMIA:000564-9615 Yes
domestic cat Felis catus OMIA:000564-9685 Yes
domestic cattle Bos taurus OMIA:000564-9913 Yes
goat Capra hircus OMIA:000564-9925 Yes
gray short-tailed opossum Monodelphis domestica OMIA:000564-13616 Yes
horse Equus caballus OMIA:000564-9796 Yes
Japanese flounder Paralichthys olivaceus OMIA:000564-8255 Unknown, not counted
Laughing kookaburra Dacelo novaeguineae OMIA:000564-8939 Unknown, not counted
llama Lama glama OMIA:000564-9844 Yes
mule Equus asinus x Equus caballus OMIA:000564-319699 Yes
pig Sus scrofa OMIA:000564-9823 Yes
raccoon dog Nyctereutes procyonoides OMIA:000564-34880 Yes
rainbow lorikeet Trichoglossus moluccanus OMIA:000564-1549204 Unknown, not counted
red deer Cervus elaphus OMIA:000564-9860 Unknown, not counted
sheep Ovis aries OMIA:000564-9940 Yes
tammar wallaby Notamacropus eugenii OMIA:000564-9315 Unknown, not counted
Trichoglossus chlorolepidotus Trichoglossus chlorolepidotus OMIA:000564-585473 Unknown, not counted
Western roe deer Capreolus capreolus OMIA:000564-9858 Yes
wolf Canis lupus OMIA:000564-9612 Yes

Genes

Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.

Species Animal gene Human gene Ortholog
argali No gene OMIA records no gene for this species entry.
bighorn sheep No gene OMIA records no gene for this species entry.
chicken No gene OMIA records no gene for this species entry.
dog No gene OMIA records no gene for this species entry.
domestic cat No gene OMIA records no gene for this species entry.
domestic cattle No gene OMIA records no gene for this species entry.
goat No gene OMIA records no gene for this species entry.
gray short-tailed opossum No gene OMIA records no gene for this species entry.
horse No gene OMIA records no gene for this species entry.
llama No gene OMIA records no gene for this species entry.
mule No gene OMIA records no gene for this species entry.
pig No gene OMIA records no gene for this species entry.
raccoon dog No gene OMIA records no gene for this species entry.
sheep No gene OMIA records no gene for this species entry.
Western roe deer No gene OMIA records no gene for this species entry.
wolf No gene OMIA records no gene for this species entry.
Australian magpie Not a defect, not counted No gene OMIA records no gene for this species entry.
crested pigeon Not a defect, not counted No gene OMIA records no gene for this species entry.
Japanese flounder Not a defect, not counted No gene OMIA records no gene for this species entry.
Laughing kookaburra Not a defect, not counted No gene OMIA records no gene for this species entry.
rainbow lorikeet Not a defect, not counted No gene OMIA records no gene for this species entry.
red deer Not a defect, not counted No gene OMIA records no gene for this species entry.
tammar wallaby Not a defect, not counted No gene OMIA records no gene for this species entry.
Trichoglossus chlorolepidotus Not a defect, not counted No gene OMIA records no gene for this species entry.

Human diseases

Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.

Mondo disease Name Found by
MONDO:0002145 disorder of sexual differentiation A congenital disorder characterized by abnormalities in the development of the sexual characteristics. OMIA's own Mondo link

Target evidence

Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.

The chain did not reach target evidence.

Drugs

The chain did not reach the drugs.