Comparative

OMIA group 747

Osteoarthritis

The chain reaches the human disease osteoarthritis susceptibility 1, which Mondo defines as: “Any osteoarthritis in which the cause of the disease is a mutation in the FRZB gene.” It reaches 5 more human diseases, listed below.

The chain

From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.

  1. Animal disease

    Reached

    OMIA records it in 8 species entries marked as a defect.

  2. Human disease

    Reached

    6 Mondo diseases.

  3. Human gene

    Stopped here

    No gene of a species entry marked as a defect reaches a human gene through Ensembl's orthologs.

  4. Target evidence

    Not reached

    The chain stopped before this step.

  5. Drugs

    Not reached

    The chain stopped before this step.

The chain stopped at Human gene: No gene of a species entry marked as a defect reaches a human gene through Ensembl's orthologs.

Natural-model score

How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.

osteoarthritis susceptibility 1

15.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog No gene of a naturally occurring entry reaches a human gene 0.0 of 20
Both routes One route found this disease 5.0 of 10
Species 8 naturally occurring species entries marked as a defect 10.0 of 10
osteoarthritis susceptibility 2

15.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog No gene of a naturally occurring entry reaches a human gene 0.0 of 20
Both routes One route found this disease 5.0 of 10
Species 8 naturally occurring species entries marked as a defect 10.0 of 10
osteoarthritis susceptibility 3

15.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog No gene of a naturally occurring entry reaches a human gene 0.0 of 20
Both routes One route found this disease 5.0 of 10
Species 8 naturally occurring species entries marked as a defect 10.0 of 10
osteoarthritis susceptibility 4

15.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog No gene of a naturally occurring entry reaches a human gene 0.0 of 20
Both routes One route found this disease 5.0 of 10
Species 8 naturally occurring species entries marked as a defect 10.0 of 10
osteoarthritis susceptibility 5

15.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog No gene of a naturally occurring entry reaches a human gene 0.0 of 20
Both routes One route found this disease 5.0 of 10
Species 8 naturally occurring species entries marked as a defect 10.0 of 10
osteoarthritis susceptibility 6

15.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog No gene of a naturally occurring entry reaches a human gene 0.0 of 20
Both routes One route found this disease 5.0 of 10
Species 8 naturally occurring species entries marked as a defect 10.0 of 10

Species

The chain follows only the species entries that OMIA marks as a defect.

Species Scientific name OMIA entry A defect
dog Canis lupus familiaris OMIA:000747-9615 Yes
domestic cat Felis catus OMIA:000747-9685 Yes
domestic guinea pig Cavia porcellus OMIA:000747-10141 Yes
horse Equus caballus OMIA:000747-9796 Yes
koala Phascolarctos cinereus OMIA:000747-38626 Yes
pig Sus scrofa OMIA:000747-9823 Yes
sea otter Enhydra lutris OMIA:000747-34882 Yes
sheep Ovis aries OMIA:000747-9940 Yes

Genes

Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.

Species Animal gene Human gene Ortholog
dog No gene OMIA records no gene for this species entry.
domestic cat No gene OMIA records no gene for this species entry.
domestic guinea pig No gene OMIA records no gene for this species entry.
horse No gene OMIA records no gene for this species entry.
koala No gene OMIA records no gene for this species entry.
pig No gene OMIA records no gene for this species entry.
sea otter No gene OMIA records no gene for this species entry.
sheep No gene OMIA records no gene for this species entry.

Human diseases

Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.

Mondo disease Name Found by
MONDO:0008143 osteoarthritis susceptibility 1 Any osteoarthritis in which the cause of the disease is a mutation in the FRZB gene. OMIA's OMIM numbers
MONDO:0007704 osteoarthritis susceptibility 2 OMIA's OMIM numbers
MONDO:0011923 osteoarthritis susceptibility 3 Any osteoarthritis in which the cause of the disease is a mutation in the ASPN gene. OMIA's OMIM numbers
MONDO:0012568 osteoarthritis susceptibility 4 OMIA's OMIM numbers
MONDO:0012893 osteoarthritis susceptibility 5 Any osteoarthritis in which the cause of the disease is a mutation in the GDF5 gene. OMIA's OMIM numbers
MONDO:0012894 osteoarthritis susceptibility 6 OMIA's OMIM numbers

Target evidence

Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.

The chain did not reach target evidence.

Drugs

The chain did not reach the drugs.