Comparative

Human disease

B-cell chronic lymphocytic leukemia

MONDO:0004948

Mondo defines it as: “B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.”

1 disease group in OMIA reaches this disease, through OMIA's own Mondo link or its OMIM numbers. The page shows the chain. It does not say whether an animal is a model of this disease.

Animal diseases

By natural-model score for this disease, highest first. The score says how complete and how well supported each chain is, by stated rules. How the score works.

OMIA group Name Found by Species The chain reached Score
2681 Leukaemia, chronic lymphocytic OMIA's OMIM numbers 1 Human disease 34.0

Human genes

Each human gene of these disease groups that Open Targets links to this disease.

Open Targets links none of these groups' human genes to this disease.

Drugs tested for this disease

Each ChEMBL drug that has been tested for this disease, and the human genes above it acts on, if any. Open Targets gives some drugs, such as most enzyme replacement therapies, no target gene.

Drug Acts on Latest stage for this disease
Acalabrutinib None of these genes Approved
Alemtuzumab None of these genes Approved
Bendamustine None of these genes Approved
Duvelisib None of these genes Approved
Fludarabine Phosphate None of these genes Approved
Ibrutinib None of these genes Approved
Idelalisib None of these genes Approved
Obinutuzumab None of these genes Approved
Ofatumumab None of these genes Approved
Rituximab None of these genes Approved
Venetoclax None of these genes Approved
Zanubrutinib None of these genes Approved
Apg-2575 None of these genes Phase 3
Arsenic Trioxide None of these genes Phase 3
Chlorambucil None of these genes Phase 3
Cladribine None of these genes Phase 3
Cyclophosphamide Anhydrous None of these genes Phase 3
Darbepoetin Alfa None of these genes Phase 3
Dinaciclib None of these genes Phase 3
Doxorubicin None of these genes Phase 3
Epoetin Alfa None of these genes Phase 3
Epoetin Beta None of these genes Phase 3
Ergocalciferol None of these genes Phase 3
Filgrastim None of these genes Phase 3
Fludarabine None of these genes Phase 3
Iron Sucrose None of these genes Phase 3
Lenalidomide None of these genes Phase 3
Lisocabtagene Maraleucel None of these genes Phase 3
Methylprednisolone None of these genes Phase 3
Mitoxantrone None of these genes Phase 3
Nemtabrutinib None of these genes Phase 3
Nx-5948 None of these genes Phase 3
Oblimersen Sodium None of these genes Phase 3
Orelabrutinib None of these genes Phase 3
Pentostatin None of these genes Phase 3
Pirtobrutinib None of these genes Phase 3
Prednisone None of these genes Phase 3
Rocbrutinib None of these genes Phase 3
Sirolimus None of these genes Phase 3
Sonrotoclax None of these genes Phase 3
Surovatamig None of these genes Phase 3
Tacrolimus Anhydrous None of these genes Phase 3
Tislelizumab None of these genes Phase 3
Ublituximab None of these genes Phase 3
Umbralisib None of these genes Phase 3
Vincristine None of these genes Phase 3
2-Mercaptoethanesulfonic Acid None of these genes Phase 2
Afuresertib None of these genes Phase 2
Aldesleukin None of these genes Phase 2
Alvocidib None of these genes Phase 2
Aminolevulinic Acid None of these genes Phase 2
An-9 None of these genes Phase 2
Antilymphocyte Immunoglobulin (Horse) None of these genes Phase 2
Apolizumab None of these genes Phase 2
Asparaginase None of these genes Phase 2
At-7519 None of these genes Phase 2
Atezolizumab None of these genes Phase 2
Auranofin None of these genes Phase 2
Azacitidine None of these genes Phase 2
Bafetinib None of these genes Phase 2
Belimumab None of these genes Phase 2
Bevacizumab None of these genes Phase 2
Bortezomib None of these genes Phase 2
Bryostatin 1 None of these genes Phase 2
Buparlisib None of these genes Phase 2
Busulfan None of these genes Phase 2
Carboplatin None of these genes Phase 2
Carmustine None of these genes Phase 2
Cediranib None of these genes Phase 2
Cenersen Sodium None of these genes Phase 2
Cholecalciferol None of these genes Phase 2
Ciprofloxacin None of these genes Phase 2
Cirmtuzumab None of these genes Phase 2
Cisplatin None of these genes Phase 2
Clarithromycin None of these genes Phase 2
Copanlisib None of these genes Phase 2
Cp-461 None of these genes Phase 2
Curcumin None of these genes Phase 2
Cyclosporine None of these genes Phase 2
Cytarabine None of these genes Phase 2
Daratumumab None of these genes Phase 2
Dasatinib Anhydrous None of these genes Phase 2
Denileukin Diftitox None of these genes Phase 2
Dexamethasone None of these genes Phase 2
Diphtheria Toxoid None of these genes Phase 2
Dolastatin-10 None of these genes Phase 2
Durvalumab None of these genes Phase 2
Elraglusib None of these genes Phase 2
Eltrombopag None of these genes Phase 2
Emavusertib None of these genes Phase 2
Entospletinib None of these genes Phase 2
Enzastaurin None of these genes Phase 2
Epcoritamab None of these genes Phase 2
Epirubicin None of these genes Phase 2
Etoposide None of these genes Phase 2
Everolimus None of these genes Phase 2
Forodesine None of these genes Phase 2
Gemcitabine None of these genes Phase 2
Givinostat None of these genes Phase 2
Glofitamab None of these genes Phase 2
Hydroxychloroquine None of these genes Phase 2
Ifosfamide None of these genes Phase 2
Imiquimod None of these genes Phase 2
Inebilizumab None of these genes Phase 2
Influenza Virus Vaccine None of these genes Phase 2
Interferon Alfa-2b None of these genes Phase 2
Invac-1, A Double Stranded Dna Plasmid Vaccine Construct Encoding Ubiquitin-Human Telomerase Reverse Transcriptase (Htert) Fusion Protein None of these genes Phase 2
Iopofosine None of these genes Phase 2
Irinotecan None of these genes Phase 2
Isosorbide None of these genes Phase 2
Lansoprazole None of these genes Phase 2
Lirilumab None of these genes Phase 2
Lmb-2 None of these genes Phase 2
Lomustine None of these genes Phase 2
Lumiliximab None of these genes Phase 2
Melphalan None of these genes Phase 2
Metformin None of these genes Phase 2
Methotrexate None of these genes Phase 2
Metronidazole None of these genes Phase 2
Mirdametinib None of these genes Phase 2
Mocetinostat None of these genes Phase 2
Molgramostim None of these genes Phase 2
Mosunetuzumab None of these genes Phase 2
Motexafin Gadolinium None of these genes Phase 2
Mycophenolate Mofetil None of these genes Phase 2
Navitoclax None of these genes Phase 2
Nelarabine None of these genes Phase 2
Nivolumab None of these genes Phase 2
Olaptesed Pegol None of these genes Phase 2
Paclitaxel None of these genes Phase 2
Pacritinib None of these genes Phase 2
Panobinostat None of these genes Phase 2
Pegfilgrastim None of these genes Phase 2
Pembrolizumab None of these genes Phase 2
Perifosine None of these genes Phase 2
Pertussis Vaccine Adsorbed None of these genes Phase 2
Polatuzumab Vedotin None of these genes Phase 2
Pomalidomide None of these genes Phase 2
Quarfloxin None of these genes Phase 2
Regramostim None of these genes Phase 2
Ridaforolimus None of these genes Phase 2
Rosomidnar None of these genes Phase 2
Ruxolitinib None of these genes Phase 2
Sapacitabine None of these genes Phase 2
Sargramostim None of these genes Phase 2
Sdx-101 None of these genes Phase 2
Selinexor None of these genes Phase 2
Sorafenib None of these genes Phase 2
Sotrastaurin None of these genes Phase 2
Streptococcus Pneumoniae Polysaccharide Conjugated To Corynebacterium Diphtheriae Crm197 None of these genes Phase 2
Sunitinib None of these genes Phase 2
Tafasitamab None of these genes Phase 2
Talabostat None of these genes Phase 2
Temsirolimus None of these genes Phase 2
Tenalisib None of these genes Phase 2
Tenofovir Alafenamide None of these genes Phase 2
Tetanus Toxoid None of these genes Phase 2
Thalidomide None of these genes Phase 2
Theophylline Anhydrous None of these genes Phase 2
Thiotepa None of these genes Phase 2
Tirabrutinib None of these genes Phase 2
Tositumomab None of these genes Phase 2
Troculeucel None of these genes Phase 2
Urelumab None of these genes Phase 2
Valproic Acid None of these genes Phase 2
Vemurafenib None of these genes Phase 2
Vismodegib None of these genes Phase 2
Vorinostat None of these genes Phase 2
Voxtalisib None of these genes Phase 2
Zandelisib None of these genes Phase 2
Acadesine None of these genes Phase 1/2
Aeg-35156 None of these genes Phase 1/2
Avadomide None of these genes Phase 1/2
Beclanorsen None of these genes Phase 1/2
Blinatumomab None of these genes Phase 1/2
Camonsertib None of these genes Phase 1/2
Carfilzomib None of these genes Phase 1/2
Cdc-801 None of these genes Phase 1/2
Cemacabtagene Ansegedleucel None of these genes Phase 1/2
Cerdulatinib None of these genes Phase 1/2
Cho-H01 None of these genes Phase 1/2
Clofarabine None of these genes Phase 1/2
Cyc-065 None of these genes Phase 1/2
Dacetuzumab None of these genes Phase 1/2
Daporinad None of these genes Phase 1/2
Dexamethasone Phosphoric Acid None of these genes Phase 1/2
Doxycycline Anhydrous None of these genes Phase 1/2
Dubermatinib None of these genes Phase 1/2
Epigalocatechin Gallate None of these genes Phase 1/2
Eprenetapopt None of these genes Phase 1/2
Etanercept None of these genes Phase 1/2
Fbt-A05 None of these genes Phase 1/2
Fostamatinib None of these genes Phase 1/2
Gossypol Acetic Acid None of these genes Phase 1/2
Gusacitinib None of these genes Phase 1/2
Hydrocortisone None of these genes Phase 1/2
Ibritumomab Tiuxetan None of these genes Phase 1/2
Imatinib None of these genes Phase 1/2
Interleukin 15, Recombinant Non-Glycosylated None of these genes Phase 1/2
Interleukin-7 None of these genes Phase 1/2
Ixazomib None of these genes Phase 1/2
Laromustine None of these genes Phase 1/2
Lenograstim None of these genes Phase 1/2
Milatuzumab None of these genes Phase 1/2
Mk-2206 None of these genes Phase 1/2
Monalizumab None of these genes Phase 1/2
Moxetumomab Pasudotox None of these genes Phase 1/2
Mt-3724 None of these genes Phase 1/2
Muromonab-Cd3 None of these genes Phase 1/2
Navtemadlin None of these genes Phase 1/2
Noscapine None of these genes Phase 1/2
Olaparib None of these genes Phase 1/2
Otlertuzumab None of these genes Phase 1/2
Oxaliplatin None of these genes Phase 1/2
Palifermin None of these genes Phase 1/2
Parsaclisib None of these genes Phase 1/2
Pyrimethamine None of these genes Phase 1/2
Rabacfosadine None of these genes Phase 1/2
Rapcabtagene Autoleucel None of these genes Phase 1/2
Recombinant Human Interleukin-15 None of these genes Phase 1/2
Rimiducid None of these genes Phase 1/2
Roginolisib None of these genes Phase 1/2
Samalizumab None of these genes Phase 1/2
Sjg-136 None of these genes Phase 1/2
Tocilizumab None of these genes Phase 1/2
Ucn-01 None of these genes Phase 1/2
Vecabrutinib None of these genes Phase 1/2
Veltuzumab None of these genes Phase 1/2
4g7xh22 None of these genes Phase 1
Abivertinib None of these genes Phase 1
Adenosine None of these genes Phase 1
Agatolimod None of these genes Phase 1
Alisertib None of these genes Phase 1
Alvespimycin None of these genes Phase 1
Amdizalisib None of these genes Phase 1
Amg-319 None of these genes Phase 1
Aplitabart None of these genes Phase 1
Ar-42 None of these genes Phase 1
Azd-5991 None of these genes Phase 1
Bi-836826 None of these genes Phase 1
Biib021 None of these genes Phase 1
Birinapant None of these genes Phase 1
Bl22 None of these genes Phase 1
Bnc-105p None of these genes Phase 1
Bosmolisib None of these genes Phase 1
Brexucabtagene Autoleucel None of these genes Phase 1
Cc-115 None of these genes Phase 1
Cd40 Ligand None of these genes Phase 1
Ceralasertib None of these genes Phase 1
Cobomarsen None of these genes Phase 1
Cosibelimab None of these genes Phase 1
Decitabine None of these genes Phase 1
Dimethyl Fumarate None of these genes Phase 1
Docetaxel Anhydrous None of these genes Phase 1
Duvortuxizumab None of these genes Phase 1
Enitociclib None of these genes Phase 1
Erythromycin None of these genes Phase 1
Evofosfamide None of these genes Phase 1
Exatecan None of these genes Phase 1
Fenebrutinib None of these genes Phase 1
Fluorouracil None of these genes Phase 1
Ganciclovir None of these genes Phase 1
Ginseng, American None of these genes Phase 1
Gnkg-168 None of these genes Phase 1
Golcadomide None of these genes Phase 1
Gs-9901 None of these genes Phase 1
Gsk-923295a None of these genes Phase 1
Hiltonol None of these genes Phase 1
Ianalumab None of these genes Phase 1
Icovamenib None of these genes Phase 1
Ipilimumab None of these genes Phase 1
Jnj-64264681 None of these genes Phase 1
Kw-2478 None of these genes Phase 1
Leucovorin None of these genes Phase 1
Lfb-R603 None of these genes Phase 1
Loncastuximab Tesirine None of these genes Phase 1
Luxeptinib None of these genes Phase 1
Magrolimab None of these genes Phase 1
Mdx-1342 None of these genes Phase 1
Mdx-1411 None of these genes Phase 1
Methoxyamine None of these genes Phase 1
Mik-Beta-1 None of these genes Phase 1
Milrebrutinib None of these genes Phase 1
Mivavotinib None of these genes Phase 1
Naratuximab Emtansine None of these genes Phase 1
Nedisertib None of these genes Phase 1
Niraparib None of these genes Phase 1
Obatoclax None of these genes Phase 1
Odronextamab None of these genes Phase 1
Onametostat None of these genes Phase 1
Pevonedistat None of these genes Phase 1
Pinatuzumab Vedotin None of these genes Phase 1
Pitavastatin None of these genes Phase 1
Plerixafor None of these genes Phase 1
Rezetamig None of these genes Phase 1
Ricolinostat None of these genes Phase 1
Rigosertib None of these genes Phase 1
Ritonavir None of these genes Phase 1
Ro-5045337 None of these genes Phase 1
Romidepsin None of these genes Phase 1
Safimaltib None of these genes Phase 1
Sf-1126 None of these genes Phase 1
Simvastatin None of these genes Phase 1
Snx 5422 None of these genes Phase 1
Sodium Salicylate None of these genes Phase 1
Sovleplenib None of these genes Phase 1
Spebrutinib None of these genes Phase 1
Talazoparib None of these genes Phase 1
Tanespimycin None of these genes Phase 1
Teglarinad None of these genes Phase 1
Temuterkib None of these genes Phase 1
Tisagenlecleucel None of these genes Phase 1
Topotecan None of these genes Phase 1
Tositumomab 131i None of these genes Phase 1
Trabectedin None of these genes Phase 1
Ulocuplumab None of these genes Phase 1
Veliparib None of these genes Phase 1
Vob-560 None of these genes Phase 1
Voriconazole None of these genes Phase 1
Voruciclib None of these genes Phase 1
Xl-844 None of these genes Phase 1
Zelebrudomide None of these genes Phase 1
Zeripatamig None of these genes Phase 1
Zotiraciclib None of these genes Phase 1
Roflumilast None of these genes Early phase 1
Human Immunoglobulin G None of these genes Unknown
Tyrosine None of these genes Unknown
Ulviprubart None of these genes Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.