Human disease
osteoporosis
Mondo defines it as: “A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).”
1 disease group in OMIA reaches this disease, through OMIA's own Mondo link or its OMIM numbers. The page shows the chain. It does not say whether an animal is a model of this disease.
Animal diseases
By natural-model score for this disease, highest first. The score says how complete and how well supported each chain is, by stated rules. How the score works.
| OMIA group | Name | Found by | Species | The chain reached | Score |
|---|---|---|---|---|---|
| 105 | Osteoporosis | The group's name | 1 | Human disease |
31.5
|
Human genes
Each human gene of these disease groups that Open Targets links to this disease.
Open Targets links none of these groups' human genes to this disease.
Drugs tested for this disease
Each ChEMBL drug that has been tested for this disease, and the human genes above it acts on, if any. Open Targets gives some drugs, such as most enzyme replacement therapies, no target gene.
| Drug | Acts on | Latest stage for this disease |
|---|---|---|
| Abaloparatide | None of these genes | Approved |
| Alendronic Acid | None of these genes | Approved |
| Bazedoxifene | None of these genes | Approved |
| Calcitonin | None of these genes | Approved |
| Calcium | None of these genes | Approved |
| Calcium Carbonate | None of these genes | Approved |
| Cholecalciferol | None of these genes | Approved |
| Cyanocobalamin | None of these genes | Approved |
| Denosumab | None of these genes | Approved |
| Eldecalcitol | None of these genes | Approved |
| Estradiol | None of these genes | Approved |
| Estrogens, Conjugated | None of these genes | Approved |
| Estrogens, Conjugated Synthetic A | None of these genes | Approved |
| Estrone Sulfuric Acid | None of these genes | Approved |
| Etidronic Acid | None of these genes | Approved |
| Folic Acid | None of these genes | Approved |
| Ibandronic Acid | None of these genes | Approved |
| Ipriflavone | None of these genes | Approved |
| Lasofoxifene | None of these genes | Approved |
| Levonorgestrel | None of these genes | Approved |
| Minodronic Acid | None of these genes | Approved |
| Nandrolone | None of these genes | Approved |
| Pyridoxine | None of these genes | Approved |
| Raloxifene | None of these genes | Approved |
| Risedronic Acid | None of these genes | Approved |
| Romosozumab | None of these genes | Approved |
| Smc021 | None of these genes | Approved |
| Sodium Fluoride | None of these genes | Approved |
| Strontium Ranelate | None of these genes | Approved |
| Teriparatide | None of these genes | Approved |
| Teriparatide Acetate | None of these genes | Approved |
| Testosterone | None of these genes | Approved |
| Tiludronic Acid | None of these genes | Approved |
| Zoledronic Acid Anhydrous | None of these genes | Approved |
| Arzoxifene | None of these genes | Phase 3 |
| Calcitonin Salmon | None of these genes | Phase 3 |
| Cinacalcet | None of these genes | Phase 3 |
| Clodronic Acid | None of these genes | Phase 3 |
| Ergocalciferol | None of these genes | Phase 3 |
| Estrogen | None of these genes | Phase 3 |
| Isosorbide Mononitrate | None of these genes | Phase 3 |
| Menatetrenone | None of these genes | Phase 3 |
| Nitroglycerin | None of these genes | Phase 3 |
| Odanacatib | None of these genes | Phase 3 |
| Parathyroid Hormone | None of these genes | Phase 3 |
| Progesterone | None of these genes | Phase 3 |
| Sitagliptin | None of these genes | Phase 3 |
| Somatropin | None of these genes | Phase 3 |
| Genistein | None of these genes | Phase 2/3 |
| Phytonadione | None of these genes | Phase 2/3 |
| Alfacalcidol | None of these genes | Phase 2 |
| Balicatib | None of these genes | Phase 2 |
| Blosozumab | None of these genes | Phase 2 |
| Calcitriol | None of these genes | Phase 2 |
| Calcium Phosphate, Dibasic | None of these genes | Phase 2 |
| Calcium Phosphate, Tribasic | None of these genes | Phase 2 |
| Dasatinib Anhydrous | None of these genes | Phase 2 |
| Deferasirox | None of these genes | Phase 2 |
| Dp001 | None of these genes | Phase 2 |
| Encaleret | None of these genes | Phase 2 |
| Evatanepag | None of these genes | Phase 2 |
| Fluoride | None of these genes | Phase 2 |
| Magnesium | None of these genes | Phase 2 |
| Mk-0773 | None of these genes | Phase 2 |
| Narlumosbart | None of these genes | Phase 2 |
| Neridronic Acid | None of these genes | Phase 2 |
| Nicotinamide Riboside | None of these genes | Phase 2 |
| Ono-5334 | None of these genes | Phase 2 |
| Ostabolin-C | None of these genes | Phase 2 |
| Quercetin | None of these genes | Phase 2 |
| Ronacaleret | None of these genes | Phase 2 |
| Rosiglitazone | None of these genes | Phase 2 |
| Rosuvastatin | None of these genes | Phase 2 |
| Sb-423562 | None of these genes | Phase 2 |
| Semparatide | None of these genes | Phase 2 |
| Sodium Chloride | None of these genes | Phase 2 |
| Sodium Pentaborate Pentahydrate | None of these genes | Phase 2 |
| Tamoxifen | None of these genes | Phase 2 |
| Apomine | None of these genes | Phase 1/2 |
| Bifidobacterium Spp. | None of these genes | Phase 1/2 |
| Pamidronic Acid | None of these genes | Phase 1/2 |
| Rivogenlecleucel | None of these genes | Phase 1/2 |
| Amg-167 | None of these genes | Phase 1 |
| Atf-936 | None of these genes | Phase 1 |
| Axt-914 | None of these genes | Phase 1 |
| Chf4227 | None of these genes | Phase 1 |
| Lgd-2941 | None of these genes | Phase 1 |
| Relacatib | None of these genes | Phase 1 |
| Resugosbart | None of these genes | Phase 1 |
| Diphyllin | None of these genes | Investigational new drug |
| Rad-140 | None of these genes | Investigational new drug |
| Benzenesulfonamide | None of these genes | Preclinical |
| Bemiparin | None of these genes | Unknown |
| Calcium Lactate | None of these genes | Unknown |
| Dalteparin Sodium | None of these genes | Unknown |
| Daniplestim | None of these genes | Unknown |
| Dibotermin Alfa | None of these genes | Unknown |
| Enoxaparin | None of these genes | Unknown |
| Enoxaparin Sodium | None of these genes | Unknown |
| Heparin | None of these genes | Unknown |
| Heparin Calcium | None of these genes | Unknown |
| Heparin Sodium | None of these genes | Unknown |
| Ibuprofen | None of these genes | Unknown |
| Letrozole | None of these genes | Unknown |
| Mecasermin | None of these genes | Unknown |
| Menaquinone | None of these genes | Unknown |
| Nadroparin Calcium | None of these genes | Unknown |
| Norethindrone Acetate | None of these genes | Unknown |
| Testosterone Undecanoate | None of these genes | Unknown |
| Tinzaparin | None of these genes | Unknown |
| Tinzaparin Sodium | None of these genes | Unknown |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.