Comparative

Human disease

myelodysplastic syndrome

MONDO:0018881

Mondo defines it as: “A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)”

1 disease group in OMIA reaches this disease, through OMIA's own Mondo link or its OMIM numbers. The page shows the chain. It does not say whether an animal is a model of this disease.

Animal diseases

By natural-model score for this disease, highest first. The score says how complete and how well supported each chain is, by stated rules. How the score works.

OMIA group Name Found by Species The chain reached Score
2870 Myelodysplastic syndrome Both routes 2 Human disease 42.0

Human genes

Each human gene of these disease groups that Open Targets links to this disease.

Open Targets links none of these groups' human genes to this disease.

Drugs tested for this disease

Each ChEMBL drug that has been tested for this disease, and the human genes above it acts on, if any. Open Targets gives some drugs, such as most enzyme replacement therapies, no target gene.

Drug Acts on Latest stage for this disease
Azacitidine None of these genes Approved
Cedazuridine None of these genes Approved
Clofarabine None of these genes Approved
Decitabine None of these genes Approved
Deferasirox None of these genes Approved
Epoetin Alfa None of these genes Approved
Filgrastim None of these genes Approved
Imetelstat None of these genes Approved
Lenalidomide None of these genes Approved
Luspatercept None of these genes Approved
Alemtuzumab None of these genes Phase 3
Antilymphocyte Immunoglobulin (Horse) None of these genes Phase 3
Apg-2575 None of these genes Phase 3
Arsenic Trioxide None of these genes Phase 3
Asparaginase None of these genes Phase 3
Asparaginase Erwinia Chrysanthemi None of these genes Phase 3
Busulfan None of these genes Phase 3
Calcitriol None of these genes Phase 3
Caspofungin None of these genes Phase 3
Cladribine None of these genes Phase 3
Cyclophosphamide Anhydrous None of these genes Phase 3
Cyclosporine None of these genes Phase 3
Cytarabine None of these genes Phase 3
Darbepoetin Alfa None of these genes Phase 3
Daunorubicin None of these genes Phase 3
Dexamethasone None of these genes Phase 3
Elritercept None of these genes Phase 3
Enasidenib None of these genes Phase 3
Epoetin Beta None of these genes Phase 3
Eprenetapopt None of these genes Phase 3
Etelcalcetide None of these genes Phase 3
Etoposide None of these genes Phase 3
Fludarabine None of these genes Phase 3
Fludarabine Phosphate None of these genes Phase 3
Gemtuzumab Ozogamicin None of these genes Phase 3
Gilteritinib None of these genes Phase 3
Glasdegib None of these genes Phase 3
Guadecitabine None of these genes Phase 3
Hydrocortisone None of these genes Phase 3
Hydroxyurea None of these genes Phase 3
Idarubicin None of these genes Phase 3
Isotretinoin None of these genes Phase 3
Ivosidenib None of these genes Phase 3
Lemzoparlimab None of these genes Phase 3
Lenograstim None of these genes Phase 3
Lonafarnib None of these genes Phase 3
Magrolimab None of these genes Phase 3
Melphalan None of these genes Phase 3
Methotrexate None of these genes Phase 3
Midostaurin None of these genes Phase 3
Mitoxantrone None of these genes Phase 3
Mycophenolate Mofetil None of these genes Phase 3
Omacetaxine Mepesuccinate None of these genes Phase 3
Omidubicel None of these genes Phase 3
Panobinostat None of these genes Phase 3
Pegfilgrastim None of these genes Phase 3
Pevonedistat None of these genes Phase 3
Recombinant Human Thrombopoietin None of these genes Phase 3
Rigosertib None of these genes Phase 3
Rituximab None of these genes Phase 3
Roxadustat None of these genes Phase 3
Sabatolimab None of these genes Phase 3
Semustine None of these genes Phase 3
Sirolimus None of these genes Phase 3
Tacrolimus Anhydrous None of these genes Phase 3
Tamibarotene None of these genes Phase 3
Thalidomide None of these genes Phase 3
Thioguanine None of these genes Phase 3
Thiotepa None of these genes Phase 3
Treosulfan None of these genes Phase 3
Tretinoin None of these genes Phase 3
Valspodar None of these genes Phase 3
Venetoclax None of these genes Phase 3
Eltrombopag None of these genes Phase 2/3
Galunisertib None of these genes Phase 2/3
Imetelstat Sodium None of these genes Phase 2/3
Methylprednisolone None of these genes Phase 2/3
Nivolumab None of these genes Phase 2/3
Quizartinib None of these genes Phase 2/3
Rafutrombopag None of these genes Phase 2/3
Rivogenlecleucel None of these genes Phase 2/3
Sorafenib None of these genes Phase 2/3
Tipifarnib None of these genes Phase 2/3
Vosaroxin None of these genes Phase 2/3
2-Mercaptoethanesulfonic Acid None of these genes Phase 2
Adavosertib None of these genes Phase 2
Aflibercept None of these genes Phase 2
Aldesleukin None of these genes Phase 2
Alisertib None of these genes Phase 2
Alovudine None of these genes Phase 2
Amifostine None of these genes Phase 2
Ammonium Trichlorotellurate None of these genes Phase 2
Amsacrine None of these genes Phase 2
Ar-67 None of these genes Phase 2
Ascorbic Acid None of these genes Phase 2
Aspacytarabine None of these genes Phase 2
Atorvastatin None of these genes Phase 2
Autologous Cord Blood None of these genes Phase 2
Axitinib None of these genes Phase 2
Belinostat None of these genes Phase 2
Bemcentinib None of these genes Phase 2
Bevacizumab None of these genes Phase 2
Bexarotene None of these genes Phase 2
Bezafibrate None of these genes Phase 2
Birinapant None of these genes Phase 2
Bomedemstat None of these genes Phase 2
Bortezomib None of these genes Phase 2
Briquilimab None of these genes Phase 2
Bryostatin 1 None of these genes Phase 2
Calcifediol Anhydrous None of these genes Phase 2
Camidanlumab Tesirine None of these genes Phase 2
Canakinumab None of these genes Phase 2
Carboplatin None of these genes Phase 2
Cdc-801 None of these genes Phase 2
Cediranib None of these genes Phase 2
Cholecalciferol None of these genes Phase 2
Cisplatin None of these genes Phase 2
Cpi 613 None of these genes Phase 2
Cusatuzumab None of these genes Phase 2
Daclizumab None of these genes Phase 2
Danazol None of these genes Phase 2
Dapagliflozin None of these genes Phase 2
Daratumumab None of these genes Phase 2
Dasatinib Anhydrous None of these genes Phase 2
Deferiprone None of these genes Phase 2
Dexrazoxane None of these genes Phase 2
Doxorubicin None of these genes Phase 2
Durvalumab None of these genes Phase 2
E-7820 None of these genes Phase 2
Emavusertib None of these genes Phase 2
Entinostat None of these genes Phase 2
Epacadostat None of these genes Phase 2
Erlotinib None of these genes Phase 2
Etanercept None of these genes Phase 2
Everolimus None of these genes Phase 2
Ezatiostat None of these genes Phase 2
Flotetuzumab None of these genes Phase 2
Gedatolisib None of these genes Phase 2
Gemtuzumab None of these genes Phase 2
Glycerol Phenylbutyrate None of these genes Phase 2
H3b-8800 None of these genes Phase 2
Hematin None of these genes Phase 2
Hma None of these genes Phase 2
Hydralazine None of these genes Phase 2
Imatinib None of these genes Phase 2
Incomplete Freund'S Adjuvant None of these genes Phase 2
Indisulam None of these genes Phase 2
Infliximab None of these genes Phase 2
Interferon Alfa-2b None of these genes Phase 2
Interferon Gamma-1b None of these genes Phase 2
Interleukin-12 Human Recombinant None of these genes Phase 2
Ipilimumab None of these genes Phase 2
Ker-047 None of these genes Phase 2
Laromustine None of these genes Phase 2
Leuprolide None of these genes Phase 2
Lintuzumab None of these genes Phase 2
Lirilumab None of these genes Phase 2
Medroxyprogesterone Acetate None of these genes Phase 2
Metoclopramide None of these genes Phase 2
Mocetinostat None of these genes Phase 2
Molgramostim None of these genes Phase 2
Molibresib None of these genes Phase 2
Momelotinib None of these genes Phase 2
Monalizumab None of these genes Phase 2
Motixafortide None of these genes Phase 2
Nerofe None of these genes Phase 2
Nicotinamide Riboside None of these genes Phase 2
Nogapendekin Alfa None of these genes Phase 2
Obatoclax None of these genes Phase 2
Octanoic Acid None of these genes Phase 2
Olaparib None of these genes Phase 2
Olutasidenib None of these genes Phase 2
Oxiglutatione None of these genes Phase 2
Pacritinib None of these genes Phase 2
Paricalcitol None of these genes Phase 2
Pembrolizumab None of these genes Phase 2
Pentostatin None of these genes Phase 2
Perifosine None of these genes Phase 2
Phenylbutanoic Acid None of these genes Phase 2
Pomalidomide None of these genes Phase 2
Pracinostat None of these genes Phase 2
Pravastatin None of these genes Phase 2
Prednisone None of these genes Phase 2
Pterostilbene None of these genes Phase 2
Regramostim None of these genes Phase 2
Ridaforolimus None of these genes Phase 2
Romidepsin None of these genes Phase 2
Romiplostim None of these genes Phase 2
Ropeginterferon Alfa-2b None of these genes Phase 2
Rosuvastatin None of these genes Phase 2
Ruxolitinib None of these genes Phase 2
Sapacitabine None of these genes Phase 2
Sargramostim None of these genes Phase 2
Sel-120 Free Base None of these genes Phase 2
Selinexor None of these genes Phase 2
Sephb4-Hsa None of these genes Phase 2
Sodium Stibogluconate None of these genes Phase 2
Sotatercept None of these genes Phase 2
Sp-420 None of these genes Phase 2
Streptococcus Pneumoniae Polysaccharide Conjugated To Corynebacterium Diphtheriae Crm197 None of these genes Phase 2
Sunitinib None of these genes Phase 2
Talacotuzumab None of these genes Phase 2
Talmapimod None of these genes Phase 2
Tebapivat None of these genes Phase 2
Temozolomide None of these genes Phase 2
Temsirolimus None of these genes Phase 2
Tomaralimab None of these genes Phase 2
Topotecan None of these genes Phase 2
Tosedostat None of these genes Phase 2
Trametinib None of these genes Phase 2
Troculeucel None of these genes Phase 2
Ustekinumab None of these genes Phase 2
Vadastuximab Talirine None of these genes Phase 2
Valproic Acid None of these genes Phase 2
Vatalanib None of these genes Phase 2
Vibecotamab None of these genes Phase 2
Vincristine None of these genes Phase 2
Vismodegib None of these genes Phase 2
Volasertib None of these genes Phase 2
Vorinostat None of these genes Phase 2
Zeprumetostat None of these genes Phase 2
Ab-8939 None of these genes Phase 1/2
Acadesine None of these genes Phase 1/2
Aclarubicin None of these genes Phase 1/2
Adakitug None of these genes Phase 1/2
Alrizomadlin None of these genes Phase 1/2
Alvocidib None of these genes Phase 1/2
At-9283 None of these genes Phase 1/2
Atezolizumab None of these genes Phase 1/2
Axatilimab None of these genes Phase 1/2
Azd-5153 None of these genes Phase 1/2
Azd-5991 None of these genes Phase 1/2
Bendamustine None of these genes Phase 1/2
Beroterkib Anhydrous None of these genes Phase 1/2
Bexmarilimab None of these genes Phase 1/2
Cg-200745 None of these genes Phase 1/2
Curcumin None of these genes Phase 1/2
Cyc-065 None of these genes Phase 1/2
Digoxin None of these genes Phase 1/2
Dordaviprone None of these genes Phase 1/2
Dubermatinib None of these genes Phase 1/2
E-6201 None of these genes Phase 1/2
Elranatamab None of these genes Phase 1/2
Eltanexor None of these genes Phase 1/2
Entospletinib None of these genes Phase 1/2
Ergocalciferol None of these genes Phase 1/2
Evorpacept None of these genes Phase 1/2
Ficlatuzumab None of these genes Phase 1/2
Filanesib None of these genes Phase 1/2
Ganetespib None of these genes Phase 1/2
Gsk2879552 None of these genes Phase 1/2
Histamine None of these genes Phase 1/2
Hydroxychloroquine None of these genes Phase 1/2
Incb-047986 None of these genes Phase 1/2
Incb-059872 None of these genes Phase 1/2
Inobrodib None of these genes Phase 1/2
Interleukin-7 None of these genes Phase 1/2
Itraconazole None of these genes Phase 1/2
Ixazomib None of these genes Phase 1/2
Kb-004 None of these genes Phase 1/2
Lb-100 None of these genes Phase 1/2
Leflunomide None of these genes Phase 1/2
Melk Inhibitor None of these genes Phase 1/2
Muromonab-Cd3 None of these genes Phase 1/2
Nefextinib None of these genes Phase 1/2
Nidanilimab None of these genes Phase 1/2
Ocifisertib None of these genes Phase 1/2
Ombipepimut-S None of these genes Phase 1/2
Oxaliplatin None of these genes Phase 1/2
Oxi-4503 None of these genes Phase 1/2
Palifermin None of these genes Phase 1/2
Pelabresib None of these genes Phase 1/2
Pemrametostat None of these genes Phase 1/2
Phorbol Myristate Acetate None of these genes Phase 1/2
Plerixafor None of these genes Phase 1/2
Ponatinib None of these genes Phase 1/2
Posaconazole None of these genes Phase 1/2
Pr1 Leukemia Peptide Vaccine None of these genes Phase 1/2
Prexigebersen None of these genes Phase 1/2
Revumenib None of these genes Phase 1/2
Rimiducid None of these genes Phase 1/2
Rogocekib None of these genes Phase 1/2
Safimestomig None of these genes Phase 1/2
Samalizumab None of these genes Phase 1/2
Seclidemstat None of these genes Phase 1/2
Sonrotoclax None of these genes Phase 1/2
Tamnorzatinib None of these genes Phase 1/2
Teclistamab None of these genes Phase 1/2
Telaglenastat None of these genes Phase 1/2
Timdarpacept None of these genes Phase 1/2
Tranylcypromine None of these genes Phase 1/2
Ubidecarenone None of these genes Phase 1/2
Ulixertinib None of these genes Phase 1/2
Vactosertib None of these genes Phase 1/2
Zilurgisertib None of these genes Phase 1/2
Abaloparatide None of these genes Phase 1
Alpelisib None of these genes Phase 1
Amv-564 None of these genes Phase 1
Anzurstobart None of these genes Phase 1
Apto-253 None of these genes Phase 1
Apvo-436 None of these genes Phase 1
Asunercept None of these genes Phase 1
Basiliximab None of these genes Phase 1
Binimetinib None of these genes Phase 1
Birabresib None of these genes Phase 1
Bisantrene None of these genes Phase 1
Bms-214662 None of these genes Phase 1
Btx-A51 None of these genes Phase 1
Calaspargase Pegol None of these genes Phase 1
Calcium None of these genes Phase 1
Camibirstat None of these genes Phase 1
Cc-11006 None of these genes Phase 1
Cenersen None of these genes Phase 1
Ceralasertib None of these genes Phase 1
Cirtuvivint None of these genes Phase 1
Crenolanib None of these genes Phase 1
Danvatirsen None of these genes Phase 1
Defactinib None of these genes Phase 1
Dolastatin-10 None of these genes Phase 1
Doxecitine None of these genes Phase 1
Dvx-201 None of these genes Phase 1
Edetate Calcium Disodium Anhydrous None of these genes Phase 1
Eganelisib None of these genes Phase 1
Enzomenib None of these genes Phase 1
Eragidomide None of these genes Phase 1
Evofosfamide None of these genes Phase 1
Exatecan None of these genes Phase 1
Fostamatinib None of these genes Phase 1
Galinpepimut-S None of these genes Phase 1
Gentulizumab None of these genes Phase 1
Gimatecan None of these genes Phase 1
Gti-2040 None of these genes Phase 1
Hiltonol None of these genes Phase 1
Hu8f4 None of these genes Phase 1
Iadademstat None of these genes Phase 1
Ibi-188 None of these genes Phase 1
Ibrutinib None of these genes Phase 1
Idh305 None of these genes Phase 1
Ilorasertib None of these genes Phase 1
Irofulven None of these genes Phase 1
Ispinesib None of these genes Phase 1
Jnj-64264681 None of these genes Phase 1
Kw-2449 None of these genes Phase 1
Leucovorin None of these genes Phase 1
Lgh-447 None of these genes Phase 1
Lurbinectedin None of these genes Phase 1
Luxeptinib None of these genes Phase 1
Mik-665 None of these genes Phase 1
Milademetan None of these genes Phase 1
Navitoclax None of these genes Phase 1
Nisevokitug None of these genes Phase 1
Nrx195183 None of these genes Phase 1
Onametostat None of these genes Phase 1
Palbociclib None of these genes Phase 1
Pegzilarginase None of these genes Phase 1
Pexmetinib None of these genes Phase 1
Plx-51107 None of these genes Phase 1
Prexasertib None of these genes Phase 1
Pyrimethamine None of these genes Phase 1
Quisinostat None of these genes Phase 1
Rebeccamycin None of these genes Phase 1
Regorafenib None of these genes Phase 1
Rezatapopt None of these genes Phase 1
Rezetamig None of these genes Phase 1
Ro-6870810 None of these genes Phase 1
S-55746 None of these genes Phase 1
Safimaltib None of these genes Phase 1
Sar-103168 None of these genes Phase 1
Selumetinib None of these genes Phase 1
Sertraline None of these genes Phase 1
Siremadlin None of these genes Phase 1
Sjg-136 None of these genes Phase 1
Sodium Salicylate None of these genes Phase 1
Sonidegib None of these genes Phase 1
Spartalizumab None of these genes Phase 1
Succimer None of these genes Phase 1
Sulanemadlin None of these genes Phase 1
Sx-682 None of these genes Phase 1
Tagraxofusp None of these genes Phase 1
Tak-243 None of these genes Phase 1
Talazoparib None of these genes Phase 1
Talfirastide None of these genes Phase 1
Tanespimycin None of these genes Phase 1
Tapotoclax None of these genes Phase 1
Tas-1553 None of these genes Phase 1
Tetrahydrouridine None of these genes Phase 1
Tocilizumab None of these genes Phase 1
Tremelimumab None of these genes Phase 1
Triapine None of these genes Phase 1
Ucn-01 None of these genes Phase 1
Uproleselan None of these genes Phase 1
Veliparib None of these genes Phase 1
Yttrium None of these genes Phase 1
Zedenoleucel None of these genes Phase 1
Deferoxamine None of these genes Unknown
Fluconazole None of these genes Unknown
Interferon None of these genes Unknown
Interferon Alfa None of these genes Unknown
Niraparib None of these genes Unknown
Peginterferon Alfa-2a None of these genes Unknown
Propranolol None of these genes Unknown
Rucaparib None of these genes Unknown
Voriconazole None of these genes Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.