Human gene

CFTR CF transmembrane conductance regulator

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group	Name	Species	Animal gene	Ortholog	The chain reached	Best score
1794	Cystic fibrosis	pig	CFTR	one to one	Drug	67.0 for cystic fibrosis
1794	Cystic fibrosis	rabbit	CFTR	one to one	Drug	67.0 for cystic fibrosis
1794	Cystic fibrosis	sheep	CFTR	one to one	Drug	67.0 for cystic fibrosis

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease	Mondo	Score	Evidence
cystic fibrosis	MONDO:0009061	0.91	18,298

Drugs

Each ChEMBL drug that acts on this gene.

Drug	How	Latest stage
Crofelemer	inhibitor	Approved
Elexacaftor	positive modulator	Approved
Ivacaftor	activator; positive modulator	Approved
Lumacaftor	stabiliser	Approved
Tezacaftor	positive modulator	Approved
Vanzacaftor	positive modulator	Approved
Bamocaftor	positive modulator	Phase 3
Galicaftor	positive modulator	Phase 2
Icenticaftor	activator	Phase 2
Iowh-032	inhibitor	Phase 2
Navocaftor	positive modulator	Phase 2
Olacaftor	positive modulator	Phase 2

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.