Human gene
ALS2 alsin Rho guanine nucleotide exchange factor ALS2
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 1492 | Axonopathy, segmental, ALS2-related | sheep | ALS2 | one to one | Target evidence |
55.5
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| infantile-onset ascending hereditary spastic paralysis | MONDO:0011797 | 0.76 | 857 |
| amyotrophic lateral sclerosis type 2, juvenile | MONDO:0008780 | 0.74 | 188 |
| juvenile primary lateral sclerosis | MONDO:0011663 | 0.74 | 68 |
Drugs
Each ChEMBL drug that acts on this gene.
No ChEMBL drug acts on this gene, among the genes with target evidence.