Comparative

Human gene

LAMA3 laminin, alpha 3

ENSG00000053747 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1677 Epidermolysis bullosa, junctionalis, LAMA3-related dog LAMA3 one to one Drug 64.5
for laryngo-onycho-cutaneous syndrome
1677 Epidermolysis bullosa, junctionalis, LAMA3-related horse LAMA3 one to one Drug 64.5
for laryngo-onycho-cutaneous syndrome

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
laryngo-onycho-cutaneous syndrome MONDO:0009513 0.77 225
junctional epidermolysis bullosa Herlitz type MONDO:0009182 0.72 345
junctional epidermolysis bullosa, non-Herlitz type MONDO:0009180 0.65 36

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Ocriplasmin hydrolytic enzyme Approved

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.