Human gene
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 2332 | Long QT syndrome, KCNQ1-related | dog | KCNQ1 | one to one | Drug |
69.3
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| long QT syndrome 1 | MONDO:0100316 | 0.85 | 1,012 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Amifampridine | blocker | Approved |
| Dalfampridine | blocker | Approved |
| Ezogabine | opener | Approved |
| Tedisamil | blocker | Approved |
| Nerispirdine | blocker | Phase 2 |
| Guanidine | blocker | Unknown |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.