Human gene

FGFR2 fibroblast growth factor receptor 2

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group	Name	Species	Animal gene	Ortholog	The chain reached	Best score
2090	Facial dysplasia syndrome	domestic cattle	FGFR2	one to one	Drug	61.8 for Crouzon syndrome

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease	Mondo	Score	Evidence
Crouzon syndrome	MONDO:0007405	0.86	541
Pfeiffer syndrome	MONDO:0007043	0.85	344
Apert syndrome	MONDO:0007041	0.83	464

Drugs

Each ChEMBL drug that acts on this gene.

Drug	How	Latest stage
E-7090	inhibitor	Approved
Erdafitinib	inhibitor	Approved
Futibatinib	inhibitor	Approved
Infigratinib	inhibitor	Approved
Nintedanib	inhibitor	Approved
Palifermin	agonist	Approved
Pemigatinib	inhibitor	Approved
Regorafenib	inhibitor	Approved
Trafermin	agonist	Approved
Bemarituzumab	inhibitor	Phase 3
Brivanib	inhibitor	Phase 3
Brivanib Alaninate	inhibitor	Phase 3
Derazantinib	inhibitor	Phase 3
Lucitanib	inhibitor	Phase 3
Orantinib	inhibitor	Phase 3
Rogaratinib	inhibitor	Phase 2/3
Enmd-981693	inhibitor	Phase 2
Fexagratinib	inhibitor	Phase 2
Fgfr Inhibitor Debio 1347	inhibitor	Phase 2
Hmpl-453	inhibitor	Phase 2
Ly-2874455	inhibitor	Phase 2
Tg100-801	inhibitor	Phase 2
Xl-999	inhibitor	Phase 2
Aprutumab Ixadotin	binding agent	Phase 1
Rg-1530	inhibitor	Phase 1
Cp-459632	inhibitor	Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.