Comparative

Human gene

FGFR3 fibroblast growth factor receptor 3

ENSG00000068078 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1703 Chondrodysplasia, FGFR3-related domestic cattle FGFR3 one to one Drug 85.9
for achondroplasia
1703 Chondrodysplasia, FGFR3-related sheep FGFR3 one to one Drug 85.9
for achondroplasia

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
achondroplasia MONDO:0007037 0.82 817
thanatophoric dysplasia type 1 MONDO:0008546 0.82 171
hypochondroplasia MONDO:0007793 0.80 298
thanatophoric dysplasia type 2 MONDO:0008547 0.79 114

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
E-7090 inhibitor Approved
Erdafitinib inhibitor Approved
Futibatinib inhibitor Approved
Infigratinib inhibitor Approved
Masitinib inhibitor Approved
Nintedanib inhibitor Approved
Pazopanib inhibitor Approved
Pemigatinib inhibitor Approved
Brivanib inhibitor Phase 3
Brivanib Alaninate inhibitor Phase 3
Derazantinib inhibitor Phase 3
Dovitinib inhibitor Phase 3
Orantinib inhibitor Phase 3
Rogaratinib inhibitor Phase 2/3
Enmd-2076 inhibitor Phase 2
Enmd-981693 inhibitor Phase 2
Fexagratinib inhibitor Phase 2
Fgfr Inhibitor Debio 1347 inhibitor Phase 2
Hmpl-453 inhibitor Phase 2
Ly-2874455 inhibitor Phase 2
Vofatamab inhibitor Phase 2
Xl-999 inhibitor Phase 2
Cp-459632 inhibitor Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.