Comparative

Human gene

TYR tyrosinase

ENSG00000077498 on Ensembl

2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
202 Coat/skin colour, oculocutaneous albinism type I (OCA1), TYR-related American mink TYR one to one Drug 67.4
for oculocutaneous albinism type 1A
202 Coat/skin colour, oculocutaneous albinism type I (OCA1), TYR-related dog TYR one to one Drug 67.4
for oculocutaneous albinism type 1A
202 Coat/skin colour, oculocutaneous albinism type I (OCA1), TYR-related domestic cat TYR one to one Drug 67.4
for oculocutaneous albinism type 1A
202 Coat/skin colour, oculocutaneous albinism type I (OCA1), TYR-related domestic cattle TYR one to one Drug 67.4
for oculocutaneous albinism type 1A
202 Coat/skin colour, oculocutaneous albinism type I (OCA1), TYR-related domestic ferret TYR one to one Drug 67.4
for oculocutaneous albinism type 1A
202 Coat/skin colour, oculocutaneous albinism type I (OCA1), TYR-related Japanese medaka tyr one to many Drug 67.4
for oculocutaneous albinism type 1A
202 Coat/skin colour, oculocutaneous albinism type I (OCA1), TYR-related red fox TYR one to one Drug 67.4
for oculocutaneous albinism type 1A
202 Coat/skin colour, oculocutaneous albinism type I (OCA1), TYR-related Rhesus monkey TYR one to one Drug 67.4
for oculocutaneous albinism type 1A
369 Feather colour, oculocutaneous albinism type I (OCA1), TYR-related chicken TYR one to one Drug 61.4
for oculocutaneous albinism type 1A

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
oculocutaneous albinism type 1A MONDO:0008745 0.85 485
oculocutaneous albinism type 1B MONDO:0011749 0.82 321

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Arbutin inhibitor Approved
Monobenzone inhibitor Approved
Mequinol inhibitor Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.