Comparative

Human gene

PSEN1 presenilin 1

ENSG00000080815 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
2493 Alzheimer disease, PSEN1-related crab-eating macaque PSEN1 one to one Drug 41.7
for Alzheimer disease 3
2493 Alzheimer disease, PSEN1-related pig PSEN1 one to one Drug 41.7
for Alzheimer disease 3
2493 Alzheimer disease, PSEN1-related white-tufted-ear marmoset PSEN1 one to one Drug 41.7
for Alzheimer disease 3

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
Alzheimer disease 3 MONDO:0011913 0.83 622

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Nirogacestat inhibitor Approved
Semagacestat inhibitor Phase 3
Tarenflurbil modulator Phase 3
Avagacestat inhibitor Phase 2
Rg-4733 inhibitor Phase 2
Begacestat inhibitor Phase 1

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.