Human gene
COL4A4 collagen, type IV, alpha 4
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 2618 | Nephropathy, COL4A4 related | dog | COL4A4 | one to one | Drug |
64.9
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| autosomal recessive Alport syndrome | MONDO:0008762 | 0.81 | 1,158 |
| hematuria, benign familial, 1 | MONDO:0007709 | 0.79 | 565 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Collagenase Clostridium Histolyticum | hydrolytic enzyme | Approved |
| Ocriplasmin | hydrolytic enzyme | Approved |
| Trc-093 | inhibitor | Phase 1 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.