Human gene
CACNA1S calcium voltage-gated channel subunit alpha1 S
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 2819 | Muscle weakness, CACNA1S-related | domestic cattle | CACNA1S | one to one | Drug |
58.3
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| congenital myopathy 18 | MONDO:0859514 | 0.77 | 652 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Amlodipine | blocker | Approved |
| Azelnidipine | blocker | Approved |
| Barnidipine | blocker | Approved |
| Benidipine | blocker | Approved |
| Bepridil | blocker | Approved |
| Cilnidipine | blocker | Approved |
| Cinnarizine | blocker | Approved |
| Clevidipine | blocker | Approved |
| Diltiazem | blocker | Approved |
| Dronedarone | blocker | Approved |
| Felodipine | blocker | Approved |
| Gabapentin | modulator | Approved |
| Gabapentin Enacarbil | modulator | Approved |
| Isradipine | blocker | Approved |
| Lacidipine | blocker | Approved |
| Lercanidipine | blocker | Approved |
| Levamlodipine | blocker | Approved |
| Manidipine 6300 | blocker | Approved |
| Nicardipine | blocker | Approved |
| Nifedipine | blocker | Approved |
| Nilvadipine | blocker | Approved |
| Nimodipine | blocker | Approved |
| Nisoldipine | blocker | Approved |
| Nitrendipine | blocker | Approved |
| Phloroglucinol | blocker | Approved |
| Pregabalin | modulator | Approved |
| Suloctidil | blocker | Approved |
| Terodiline | blocker | Approved |
| Verapamil | blocker | Approved |
| Imagabalin | modulator | Phase 3 |
| Atagabalin | modulator | Phase 2 |
| Azd1305 | blocker | Phase 2 |
| Elpetrigine | blocker | Phase 1 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.