Human gene

F11 coagulation factor XI

2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group	Name	Species	Animal gene	Ortholog	The chain reached	Best score
363	Factor XI deficiency	dog	F11	one to one	Drug	69.4 for congenital factor XI deficiency
363	Factor XI deficiency	domestic cattle	F11	one to one	Drug	69.4 for congenital factor XI deficiency
819	Prekallikrein deficiency	dog	KLKB1	one to one	Drug	64.9 for inherited prekallikrein deficiency

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease	Mondo	Score	Evidence
congenital factor XI deficiency	MONDO:0012897	0.77	319
inherited prekallikrein deficiency	MONDO:0012901	0.03	2

Drugs

Each ChEMBL drug that acts on this gene.

Drug	How	Latest stage
Human C1-Esterase Inhibitor	inhibitor	Approved
Abelacimab	inhibitor	Phase 3
Milvexian	inhibitor	Phase 3
Osocimab	negative allosteric modulator	Phase 2

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.