Comparative

Human gene

MYH7 myosin, heavy chain 7, cardiac muscle, beta

ENSG00000092054 on Ensembl

2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1200 Tremor, high-frequency pig MYH7 one to one Drug 62.5
for congenital myopathy 7A, myosin storage, autosomal dominant
2212 Cardiomyopathy, hypertrophic, MYH7-related domestic cat MYH7 one to one Drug 61.0
for hypertrophic cardiomyopathy 1
2212 Cardiomyopathy, hypertrophic, MYH7-related pig MYH7 one to one Drug 61.0
for hypertrophic cardiomyopathy 1
2212 Cardiomyopathy, hypertrophic, MYH7-related rabbit MYH7 one to one Drug 61.0
for hypertrophic cardiomyopathy 1

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
congenital myopathy 7A, myosin storage, autosomal dominant MONDO:0008409 0.80 470
MYH7-related skeletal myopathy MONDO:0008050 0.78 444
hypertrophic cardiomyopathy 1 MONDO:0008647 0.76 679

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Mavacamten inhibitor Approved
Omecamtiv Mecarbil activator Approved
Danicamtiv activator Phase 2/3

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.