Human gene

JAK2 Janus kinase 2

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group	Name	Species	Animal gene	Ortholog	The chain reached	Best score
809	Polycythemia	dog	JAK2	one to one	Drug	88.2 for acquired polycythemia vera

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease	Mondo	Score	Evidence
acquired polycythemia vera	MONDO:0009891	0.80	2,129
primary familial polycythemia due to EPO receptor mutation	MONDO:0007572	0.53	21

Drugs

Each ChEMBL drug that acts on this gene.

Drug	How	Latest stage
Baricitinib	inhibitor	Approved
Delgocitinib	inhibitor	Approved
Fedratinib	inhibitor	Approved
Filgotinib	inhibitor	Approved
Lestaurtinib	inhibitor	Approved
Momelotinib	inhibitor	Approved
Pacritinib	inhibitor	Approved
Ruxolitinib	inhibitor	Approved
Tofacitinib	inhibitor	Approved
Upadacitinib	inhibitor	Approved
At-9283	inhibitor	Phase 3
Peficitinib	inhibitor	Phase 3
Xl-019	inhibitor	Phase 3
Izencitinib	inhibitor	Phase 2/3
Azd-1480	inhibitor	Phase 2
Bms-911543	inhibitor	Phase 2
Gandotinib	inhibitor	Phase 2
Gusacitinib	inhibitor	Phase 2
Nezulcitinib	inhibitor	Phase 2
Ns-018	inhibitor	Phase 2
Zotiraciclib	inhibitor	Phase 1/2
Ac-430	inhibitor	Phase 1
Ct-1578	inhibitor	Phase 1
Ls-104	inhibitor	Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.