Comparative

Human gene

ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase

ENSG00000097007 on Ensembl

3 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1513 Leukaemia, chronic myelogenous dog ABL1 one to one Drug 85.8
for chronic myeloid leukemia
1513 Leukaemia, chronic myelogenous pig ABL1 one to one Drug 85.8
for chronic myeloid leukemia
1573 Leukaemia, chronic monocytic dog ABL1 one to one Drug 82.8
for chronic myeloid leukemia
2299 Leukaemia, chronic myelomonocytic dog ABL1 one to one Drug 56.7
for juvenile myelomonocytic leukemia

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
chronic myeloid leukemia MONDO:0011996 0.82 7,216
juvenile myelomonocytic leukemia MONDO:0011908 0.08 11

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Asciminib inhibitor Approved
Bosutinib inhibitor Approved
Dasatinib Anhydrous inhibitor Approved
Flumatinib inhibitor Approved
Imatinib inhibitor Approved
Nilotinib inhibitor Approved
Ponatinib inhibitor Approved
Regorafenib inhibitor Approved
Umbralisib inhibitor Approved
At-9283 inhibitor Phase 3
Olverembatinib inhibitor Phase 3
Radotinib inhibitor Phase 3
Ruserontinib inhibitor Phase 3
Saracatinib inhibitor Phase 2/3
Bafetinib inhibitor Phase 2
Vodobatinib inhibitor Phase 2
Rebastinib inhibitor Phase 1/2
Azd-0424 inhibitor Phase 1
Kw-2449 inhibitor Phase 1
Xl-228 inhibitor Phase 1
Azm-475271 inhibitor Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.