Human gene
COL1A1 collagen type I alpha 1
2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 2127 | Osteogenesis imperfecta, type II, COL1A1-related | domestic cattle | COL1A1 | one to one | Drug |
64.1
|
| 2127 | Osteogenesis imperfecta, type II, COL1A1-related | sheep | COL1A1 | one to one | Drug |
64.1
|
| 2126 | Osteogenesis imperfecta, type III, COL1A1-related | dog | COL1A1 | one to one | Drug |
60.7
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| osteogenesis imperfecta type 2 | MONDO:0008147 | 0.84 | 277 |
| osteogenesis imperfecta type 3 | MONDO:0009804 | 0.84 | 218 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Collagenase Clostridium Histolyticum | hydrolytic enzyme | Approved |
| Ocriplasmin | hydrolytic enzyme | Approved |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.