Comparative

Human gene

VWF von Willebrand factor

ENSG00000110799 on Ensembl

4 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1056 Von Willebrand disease, generic pig VWF one to one Drug 65.4
for von Willebrand disease 3
1058 Von Willebrand disease III dog VWF one to one Drug 65.4
for von Willebrand disease 3
1058 Von Willebrand disease III pig VWF one to one Drug 65.4
for von Willebrand disease 3
1339 Von Willebrand disease II dog VWF one to one Drug 63.4
for von Willebrand disease 2
1057 Von Willebrand disease I dog VWF one to one Drug 62.1
for von Willebrand disease 1

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
von Willebrand disease 2 MONDO:0013304 0.82 354
von Willebrand disease 3 MONDO:0010191 0.80 385
von Willebrand disease 1 MONDO:0008668 0.79 416
platelet-type von Willebrand disease MONDO:0008332 0.61 2,055
Bernard-Soulier syndrome MONDO:0009276 0.07 79

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Caplacizumab inhibitor Approved
Vonicog Alfa exogenous protein Approved
Von Willebrand Factor Human exogenous protein Approved
Egaptivon Pegol inhibitor Phase 2

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.