Human gene
TRPV4 transient receptor potential cation channel, subfamily V, member 4
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 319 | Ears, folded (drop vs prick) | domestic cat | TRPV4 | one to one | Drug |
60.7
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| metatropic dysplasia | MONDO:0007986 | 0.84 | 188 |
| spondylometaphyseal dysplasia, Kozlowski type | MONDO:0008477 | 0.82 | 157 |
| Charcot-Marie-Tooth disease axonal type 2C | MONDO:0011633 | 0.80 | 1,086 |
| neuronopathy, distal hereditary motor, autosomal dominant 8 | MONDO:0010839 | 0.75 | 140 |
| familial digital arthropathy-brachydactyly | MONDO:0011732 | 0.72 | 28 |
| autosomal dominant brachyolmia | MONDO:0007232 | 0.71 | 140 |
| spondyloepimetaphyseal dysplasia, Maroteaux type | MONDO:0008473 | 0.68 | 27 |
| parastremmatic dwarfism | MONDO:0008196 | 0.65 | 28 |
| scapuloperoneal spinal muscular atrophy, autosomal dominant | MONDO:0008408 | 0.53 | 23 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Butamben | inhibitor | Approved |
| Gsk2798745 | antagonist | Phase 2 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.