Comparative

Human gene

VDR vitamin D (1,25- dihydroxyvitamin D3) receptor

ENSG00000111424 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1431 Vitamin D-deficiency rickets, type II dog VDR one to one Drug 63.2
for vitamin D-dependent rickets, type 2
1431 Vitamin D-deficiency rickets, type II domestic cat VDR one to one Drug 63.2
for vitamin D-dependent rickets, type 2

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
vitamin D-dependent rickets, type 2 MONDO:0019642 0.82 392

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Alfacalcidol agonist Approved
Calcipotriene agonist Approved
Calcitriol agonist Approved
Cholecalciferol agonist Approved
Dihydrotachysterol agonist Approved
Doxercalciferol agonist Approved
Eldecalcitol agonist Approved
Ergocalciferol agonist Approved
Paricalcitol agonist Approved
Pefcalcitol agonist Phase 3
Seocalcitol agonist Phase 3
Becocalcidiol agonist Phase 2
Dp001 agonist Phase 2
Elocalcitol agonist Phase 2
Inecalcitol agonist Phase 2
Lunacalcipol agonist Phase 2
Ilx23-7553 agonist Phase 1
Calcifediol Anhydrous agonist Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.