Human gene
GHR growth hormone receptor
2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 309 | Dwarfism, sex-linked | chicken | GHR | one to one | Drug |
83.1
|
| 1323 | Dwarfism, GHR-related | pig | GHR | one to one | Drug |
63.1
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| Laron syndrome | MONDO:0009877 | 0.83 | 469 |
| short stature due to partial GHR deficiency | MONDO:0011420 | 0.76 | 48 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Lonapegsomatropin | agonist | Approved |
| Pegvisomant | antagonist | Approved |
| Somapacitan | agonist | Approved |
| Somatrem | agonist | Approved |
| Somatrogon | agonist | Approved |
| Somatropin | agonist | Approved |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.