Human gene
TPO thyroid peroxidase
2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 536 | Hypothyroidism, congenital | dog | TPO | one to one | Human gene |
40.0
|
| 2380 | Thyroid follicular cell carcinoma, predisposition to | dog | TPO | one to one | Drug |
33.1
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| familial papillary thyroid carcinoma with renal papillary neoplasia | MONDO:0011578 | 0.05 | 3 |
| thyroid cancer, nonmedullary, 1 | MONDO:0008567 | 0.04 | 2 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Carbimazole | inhibitor | Approved |
| Methimazole | inhibitor | Approved |
| Propylthiouracil | inhibitor | Approved |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.