Human gene
PLG plasminogen
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 2020 | Ligneous membranitis | dog | PLG | one to many | Drug |
69.5
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| hypoplasminogenemia | MONDO:0009009 | 0.81 | 237 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Aminocaproic Acid | inhibitor | Approved |
| Anistreplase | activator | Approved |
| Aprotinin | inhibitor | Approved |
| Defibrotide | activator | Approved |
| Defibrotide Sodium | activator | Approved |
| Streptokinase | activator | Approved |
| Tranexamic Acid | inhibitor | Approved |
| Amediplase | activator | Phase 3 |
| Desmoteplase | activator | Phase 3 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.