Comparative

Human gene

LDLR low density lipoprotein receptor

ENSG00000130164 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
499 Hypercholesterolaemia domestic cat LDLR one to one Target evidence 65.5
for hypercholesterolemia, familial, 1
499 Hypercholesterolaemia golden hamster Ldlr one to one Target evidence 65.5
for hypercholesterolemia, familial, 1
499 Hypercholesterolaemia pig LDLR one to one Target evidence 65.5
for hypercholesterolemia, familial, 1
499 Hypercholesterolaemia Rhesus monkey LDLR one to one Target evidence 65.5
for hypercholesterolemia, familial, 1

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
hypercholesterolemia, familial, 1 MONDO:0007750 0.87 2,998

Drugs

Each ChEMBL drug that acts on this gene.

No ChEMBL drug acts on this gene, among the genes with target evidence.