Human gene
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 1547 | Wingless-2 | chicken | RAF1 | one to one | Drug |
58.3
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| Noonan syndrome 5 | MONDO:0012690 | 0.77 | 176 |
| LEOPARD syndrome 2 | MONDO:0012691 | 0.71 | 121 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Regorafenib | inhibitor | Approved |
| Sorafenib | inhibitor | Approved |
| Tovorafenib | inhibitor | Approved |
| Naporafenib | inhibitor | Phase 3 |
| Belvarafenib | inhibitor | Phase 2 |
| Xl-281 | inhibitor | Phase 1/2 |
| Ly-3009120 | inhibitor | Phase 1 |
| Arq-736 Free Acid | inhibitor | Unknown |
| Lgx-806 | inhibitor | Unknown |
| Rg-7376 | inhibitor | Unknown |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.