Human gene
KRAS Kirsten rat sarcoma viral oncogene homolog
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 1990 | Cancer, TP53-related | pig | KRAS | one to one | Drug |
84.9
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| acute myeloid leukemia | MONDO:0018874 | 0.75 | 618 |
| urinary bladder cancer | MONDO:0001187 | 0.70 | 153 |
| autoimmune lymphoproliferative syndrome type 4 | MONDO:0013767 | 0.70 | 64 |
| familial pancreatic carcinoma | MONDO:0015278 | 0.67 | 3,974 |
| lung cancer | MONDO:0008903 | 0.65 | 4,284 |
| hereditary breast carcinoma | MONDO:0016419 | 0.60 | 29 |
| colorectal cancer | MONDO:0005575 | 0.53 | 5,006 |
| hepatocellular carcinoma | MONDO:0007256 | 0.51 | 498 |
| CDH1-related diffuse gastric and lobular breast cancer syndrome | MONDO:0100488 | 0.37 | 3 |
| Li-Fraumeni syndrome | MONDO:0018875 | 0.01 | 4 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Adagrasib | inhibitor | Approved |
| Sotorasib | inhibitor | Approved |
| Salirasib | inhibitor | Phase 2 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.