Human gene
EDNRB endothelin receptor type B
2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 629 | Megacolon | horse | EDNRB | one to one | Drug |
64.7
|
| 1765 | Waardenburg syndrome, type 4A | sheep | EDNRB | one to one | Drug |
58.7
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| Waardenburg syndrome type 4A | MONDO:0010192 | 0.78 | 56 |
| ABCD syndrome | MONDO:0010895 | 0.65 | 21 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Ambrisentan | antagonist | Approved |
| Aprocitentan | antagonist | Approved |
| Bosentan | antagonist | Approved |
| Macitentan | antagonist | Approved |
| Sitaxentan | antagonist | Approved |
| Darusentan | antagonist | Phase 3 |
| Tezosentan | antagonist | Phase 3 |
| Enrasentan | antagonist | Phase 2 |
| Rg-7636 | binding agent | Phase 1 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.