Comparative

Human gene

MSTN myostatin

ENSG00000138379 on Ensembl

2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
683 Muscular hypertrophy (double muscling) domestic cattle MSTN one to one Drug 54.1
for myostatin-related muscle hypertrophy
2161 Leg weakness, MSTN-related pig MSTN one to one Drug 49.1
for myostatin-related muscle hypertrophy

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
myostatin-related muscle hypertrophy MONDO:0013598 0.50 57

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Apitegromab inhibitor Phase 3
Domagrozumab inhibitor Phase 2
Landogrozumab inhibitor Phase 2
Ramatercept inhibitor Phase 2
Trevogrumab inhibitor Phase 2
Stamulumab inhibitor Phase 1/2
Pf-03446879 inhibitor Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.