Human gene

CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group	Name	Species	Animal gene	Ortholog	The chain reached	Best score
17	Adrenal insufficiency, congenital, CYP11A1-related	rabbit	CYP11A1	one to one	Drug	64.6 for Congenital adrenal insufficiency with 46, XY sex reversal OR 46,XY disorder of sex development-adrenal insufficiency due to CYP11A1 deficiency

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease	Mondo	Score	Evidence
Congenital adrenal insufficiency with 46, XY sex reversal OR 46,XY disorder of sex development-adrenal insufficiency due to CYP11A1 deficiency	MONDO:0013400	0.80	148

Drugs

Each ChEMBL drug that acts on this gene.

Drug	How	Latest stage
Aminoglutethimide	inhibitor	Approved
Levoketoconazole	inhibitor	Approved
Mitotane	inhibitor	Approved

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.