Human gene
TP53 tumor protein p53
2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 1990 | Cancer, TP53-related | crab-eating macaque | TP53 | one to one | Drug |
84.9
|
| 1990 | Cancer, TP53-related | dog | TP53 | one to one | Drug |
84.9
|
| 1990 | Cancer, TP53-related | golden hamster | Tp53 | one to one | Drug |
84.9
|
| 1990 | Cancer, TP53-related | pig | TP53 | one to one | Drug |
84.9
|
| 620 | Histiocytosis, malignant | dog | TP53 | one to one | Animal disease only |
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| Li-Fraumeni syndrome | MONDO:0018875 | 0.87 | 5,740 |
| hepatocellular carcinoma | MONDO:0007256 | 0.80 | 6,833 |
| colorectal cancer | MONDO:0005575 | 0.75 | 4,421 |
| basal cell carcinoma, susceptibility to, 7 | MONDO:0013876 | 0.74 | 91 |
| hereditary breast carcinoma | MONDO:0016419 | 0.74 | 197 |
| acute myeloid leukemia | MONDO:0018874 | 0.72 | 3,572 |
| bone osteosarcoma | MONDO:0002629 | 0.71 | 78 |
| adrenocortical carcinoma, hereditary | MONDO:0008734 | 0.71 | 227 |
| urinary bladder cancer | MONDO:0001187 | 0.71 | 1,547 |
| familial pancreatic carcinoma | MONDO:0015278 | 0.70 | 2,186 |
| glioma susceptibility 1 | MONDO:0024498 | 0.69 | 66 |
| nasopharyngeal carcinoma, susceptibility to, 1 | MONDO:0011775 | 0.50 | 3 |
| lung cancer | MONDO:0008903 | 0.40 | 5,142 |
| autoimmune lymphoproliferative syndrome type 4 | MONDO:0013767 | 0.06 | 6 |
| CDH1-related diffuse gastric and lobular breast cancer syndrome | MONDO:0100488 | 0.01 | 12 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Contusugene Ladenovec | exogenous gene | Phase 3 |
| Eprenetapopt | stabiliser | Phase 3 |
| Idasanutlin | inhibitor | Phase 3 |
| Navtemadlin | inhibitor | Phase 3 |
| Teprasiran | rnai inhibitor | Phase 3 |
| Alrizomadlin | inhibitor | Phase 2 |
| Cenersen | antisense inhibitor | Phase 2 |
| Cenersen Sodium | antisense inhibitor | Phase 2 |
| Siremadlin | inhibitor | Phase 2 |
| Teprasiran Sodium | rnai inhibitor | Unknown |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.