Human gene
CACNA1A calcium voltage-gated channel subunit alpha1 A
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 1270 | Convulsions and ataxia, CACNA1A-related | domestic cattle | CACNA1A | one to one | Drug |
73.5
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| episodic ataxia type 2 | MONDO:0007163 | 0.84 | 3,595 |
| developmental and epileptic encephalopathy, 42 | MONDO:0014917 | 0.81 | 3,270 |
| spinocerebellar ataxia type 6 | MONDO:0008457 | 0.77 | 450 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Bepridil | blocker | Approved |
| Gabapentin | modulator | Approved |
| Gabapentin Enacarbil | modulator | Approved |
| Phloroglucinol | blocker | Approved |
| Pregabalin | modulator | Approved |
| Suloctidil | blocker | Approved |
| Terodiline | blocker | Approved |
| Imagabalin | modulator | Phase 3 |
| Atagabalin | modulator | Phase 2 |
| Elpetrigine | blocker | Phase 1 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.