Human gene

IL2RG interleukin 2 receptor, gamma

2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group	Name	Species	Animal gene	Ortholog	The chain reached	Best score
899	Severe combined immunodeficiency disease, X-linked	dog	IL2RG	one to one	Drug	72.4 for combined immunodeficiency, X-linked
899	Severe combined immunodeficiency disease, X-linked	golden hamster	Il2rg	one to one	Drug	72.4 for combined immunodeficiency, X-linked
899	Severe combined immunodeficiency disease, X-linked	pig	IL2RG	one to one	Drug	72.4 for combined immunodeficiency, X-linked
2763	Severe combined immunodeficiency disease, IL2RG and RAG1-related	crab-eating macaque	IL2RG	one to one	Drug	47.2 for T-B+ severe combined immunodeficiency due to gamma chain deficiency

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease	Mondo	Score	Evidence
T-B+ severe combined immunodeficiency due to gamma chain deficiency	MONDO:0010315	0.85	628
combined immunodeficiency, X-linked	MONDO:0010730	0.74	31
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive	MONDO:0011086	0.05	1

Drugs

Each ChEMBL drug that acts on this gene.

Drug	How	Latest stage
Aldesleukin	agonist	Approved
Basiliximab	inhibitor	Approved
Daclizumab	inhibitor	Approved
Denileukin Diftitox	binding agent	Approved
Nogapendekin Alfa Inbakicept	agonist	Approved
Simlukafusp Alfa	binding agent	Phase 3
Pegenzileukin	agonist	Phase 2
Recombinant Human Interleukin-15	agonist	Phase 2

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.