Comparative

Human gene

KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

ENSG00000157404 on Ensembl

4 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1516 Gastrointestinal stromal tumour dog KIT one to one Drug 85.2
for gastrointestinal stromal tumor
209 Coat colour, dominant white domestic cattle KIT one to one Drug 63.1
for piebaldism
209 Coat colour, dominant white horse KIT one to one Drug 63.1
for piebaldism
2287 Hypopigmentation and deafness pig KIT one to one Drug 60.1
for piebaldism
426 Gonadal hypoplasia domestic cattle KIT one to one Animal disease only

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
gastrointestinal stromal tumor MONDO:0011719 0.89 7,740
piebaldism MONDO:0008244 0.82 204

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Avapritinib inhibitor Approved
Catequentinib inhibitor Approved
Cediranib inhibitor Approved
Dasatinib Anhydrous inhibitor Approved
Imatinib inhibitor Approved
Masitinib inhibitor Approved
Midostaurin inhibitor Approved
Pazopanib inhibitor Approved
Pexidartinib inhibitor Approved
Quizartinib inhibitor Approved
Regorafenib inhibitor Approved
Ripretinib inhibitor Approved
Sorafenib inhibitor Approved
Sunitinib inhibitor Approved
Tivozanib inhibitor Approved
Dovitinib inhibitor Phase 3
Famitinib inhibitor Phase 3
Motesanib inhibitor Phase 3
Semaxanib inhibitor Phase 3
Seralutinib inhibitor Phase 3
Vatalanib inhibitor Phase 3
Amuvatinib inhibitor Phase 2
Briquilimab inhibitor Phase 2
Cm-082 inhibitor Phase 2
Enmd-2076 inhibitor Phase 2
Foretinib inhibitor Phase 2
Su-014813 inhibitor Phase 2
Tandutinib inhibitor Phase 2
Telatinib inhibitor Phase 2
Xl-820 inhibitor Phase 2
Xl-999 inhibitor Phase 2
Osi-930 inhibitor Phase 1

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.