Comparative

Human gene

ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

ENSG00000160255 on Ensembl

2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
595 Leukocyte adhesion deficiency, type I dog ITGB2 one to one Drug 84.0
for leukocyte adhesion deficiency 1
595 Leukocyte adhesion deficiency, type I domestic cat ITGB2 one to one Drug 84.0
for leukocyte adhesion deficiency 1
595 Leukocyte adhesion deficiency, type I domestic cattle ITGB2 one to one Drug 84.0
for leukocyte adhesion deficiency 1
2073 Mannheimia haemolytica, susceptibility/resistance to domestic cattle ITGB2 one to one Animal disease only

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
leukocyte adhesion deficiency 1 MONDO:0007293 0.83 911

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Efalizumab inhibitor Approved
Lifitegrast antagonist Approved
Erlizumab negative modulator Unknown
Mln-01 inhibitor Unknown
Mlnm-2201 inhibitor Unknown
Rovelizumab antagonist Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.