Comparative

Human gene

LMNA lamin A/C

ENSG00000160789 on Ensembl

2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1213 Premature senesence pig LMNA one to one Target evidence 83.0
for Hutchinson-Gilford progeria syndrome
1213 Premature senesence rabbit LMNA one to one Target evidence 83.0
for Hutchinson-Gilford progeria syndrome
2796 Cardiomyopathy, dilated, LMNA-related crab-eating macaque LMNA one to one Target evidence 61.8
for dilated cardiomyopathy 1A
2796 Cardiomyopathy, dilated, LMNA-related dog LMNA one to one Target evidence 61.8
for dilated cardiomyopathy 1A

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
Hutchinson-Gilford progeria syndrome MONDO:0008310 0.83 1,388
dilated cardiomyopathy 1A MONDO:0007269 0.79 392

Drugs

Each ChEMBL drug that acts on this gene.

No ChEMBL drug acts on this gene, among the genes with target evidence.