Human gene
KLKB1 kallikrein B, plasma (Fletcher factor) 1
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 819 | Prekallikrein deficiency | dog | KLKB1 | one to one | Drug |
64.9
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| inherited prekallikrein deficiency | MONDO:0012901 | 0.72 | 30 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Aprotinin | inhibitor | Approved |
| Berotralstat | inhibitor | Approved |
| Ecallantide | inhibitor | Approved |
| Human C1-Esterase Inhibitor | inhibitor | Approved |
| Lanadelumab | inhibitor | Approved |
| Avoralstat | inhibitor | Phase 3 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.