Human gene
COL1A2 collagen, type I, alpha 2
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 2112 | Osteogenesis imperfecta, COL1A2-related | dog | COL1A2 | one to one | Drug |
64.1
|
| 2112 | Osteogenesis imperfecta, COL1A2-related | domestic cattle | COL1A2 | one to one | Drug |
64.1
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| osteogenesis imperfecta type 2 | MONDO:0008147 | 0.85 | 172 |
| osteogenesis imperfecta type 3 | MONDO:0009804 | 0.83 | 175 |
| osteogenesis imperfecta type 4 | MONDO:0008148 | 0.82 | 195 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Collagenase Clostridium Histolyticum | hydrolytic enzyme | Approved |
| Ocriplasmin | hydrolytic enzyme | Approved |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.