Comparative

Human gene

TPP1 tripeptidyl peptidase I

ENSG00000166340 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1472 Neuronal ceroid lipofuscinosis, 2 crab-eating macaque TPP1 one to one Target evidence 92.0
for neuronal ceroid lipofuscinosis 2
1472 Neuronal ceroid lipofuscinosis, 2 dog TPP1 one to one Target evidence 92.0
for neuronal ceroid lipofuscinosis 2
1472 Neuronal ceroid lipofuscinosis, 2 pig TPP1 one to one Target evidence 92.0
for neuronal ceroid lipofuscinosis 2

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
neuronal ceroid lipofuscinosis 2 MONDO:0008769 0.86 584
autosomal recessive spinocerebellar ataxia 7 MONDO:0012235 0.78 112

Drugs

Each ChEMBL drug that acts on this gene.

No ChEMBL drug acts on this gene, among the genes with target evidence.