Human gene

RAG1 recombination activating gene 1

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group	Name	Species	Animal gene	Ortholog	The chain reached	Best score
1574	Severe combined immunodeficiency disease, autosomal, T cell-negative, B cell-negative, NK cell-positive	chicken	RAG1	one to one	Target evidence	62.0 for severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive
1574	Severe combined immunodeficiency disease, autosomal, T cell-negative, B cell-negative, NK cell-positive	dog	RAG1	one to one	Target evidence	62.0 for severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive
1574	Severe combined immunodeficiency disease, autosomal, T cell-negative, B cell-negative, NK cell-positive	pig	RAG1	one to one	Target evidence	62.0 for severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease	Mondo	Score	Evidence
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive	MONDO:0011086	0.80	973

Drugs

Each ChEMBL drug that acts on this gene.

No ChEMBL drug acts on this gene, among the genes with target evidence.