Human gene
BEST1 bestrophin 1
4 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 1444 | Multifocal retinopathy 1 | dog | BEST1 | one to one | Target evidence |
58.6
|
| 1553 | Multifocal retinopathy 2 | dog | BEST1 | one to one | Target evidence |
58.6
|
| 1554 | Multifocal retinopathy 3 | dog | BEST1 | one to one | Target evidence |
58.6
|
| 2976 | Macular dystrophy, BEST1-related | crab-eating macaque | BEST1 | one to one | Target evidence |
58.6
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| vitelliform macular dystrophy 2 | MONDO:0007931 | 0.85 | 544 |
| autosomal recessive bestrophinopathy | MONDO:0012733 | 0.82 | 249 |
| autosomal dominant vitreoretinochoroidopathy | MONDO:0008662 | 0.78 | 140 |
| retinitis pigmentosa 50 | MONDO:0013175 | 0.76 | 42 |
| BEST1-related dominant retinopathy | MONDO:0700238 | 0.58 | 9 |
Drugs
Each ChEMBL drug that acts on this gene.
No ChEMBL drug acts on this gene, among the genes with target evidence.