Comparative

Human gene

MAP2K1 mitogen-activated protein kinase kinase 1

ENSG00000169032 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1512 Transitional cell carcinoma dog MAP2K1 one to one Drug 62.0
for urinary bladder cancer

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
urinary bladder cancer MONDO:0001187 0.07 15

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Binimetinib inhibitor Approved
Cobimetinib inhibitor Approved
Mirdametinib inhibitor Approved
Selumetinib inhibitor Approved
Trametinib inhibitor Approved
Avutometinib inhibitor Phase 3
Refametinib inhibitor Phase 3
Ci-1040 inhibitor Phase 2
E-6201 inhibitor Phase 2
Pimasertib inhibitor Phase 2
Tak-733 inhibitor Phase 2
Wx-554 inhibitor Phase 1/2
As-703988 inhibitor Phase 1
Azd-8330 inhibitor Phase 1
Rg-7167 inhibitor Phase 1
Ro-4987655 inhibitor Phase 1
Balamapimod inhibitor Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.