Human gene
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 1564 | Bleeding disorder, P2RY12-related | dog | P2RY12 | one to one | Drug |
62.0
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| platelet-type bleeding disorder 8 | MONDO:0012354 | 0.73 | 17 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Cangrelor | antagonist; inhibitor | Approved |
| Clopidogrel | antagonist | Approved |
| Prasugrel | antagonist | Approved |
| Ticagrelor | negative allosteric modulator | Approved |
| Ticlopidine | antagonist | Approved |
| Selatogrel | antagonist | Phase 3 |
| Elinogrel | antagonist | Phase 2 |
| Regrelor | antagonist | Unknown |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.