Comparative

Human gene

GAA glucosidase, alpha; acid

ENSG00000171298 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
419 Glycogen storage disease II dog GAA one to one Drug 61.3
for glycogen storage disease due to acid maltase deficiency, infantile onset
419 Glycogen storage disease II domestic cattle GAA one to one Drug 61.3
for glycogen storage disease due to acid maltase deficiency, infantile onset

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
glycogen storage disease due to acid maltase deficiency, infantile onset MONDO:0017694 0.68 29

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Miglitol inhibitor Approved
Voglibose inhibitor Approved
Duvoglustat stabiliser Phase 3
Celgosivir inhibitor Phase 2

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.